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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1991 Nov;54(11):972–975. doi: 10.1136/jnnp.54.11.972

Neuropathological features of Alzheimer's disease in non-demented parkinsonian patients.

S E Daniel 1, A J Lees 1
PMCID: PMC1014618  PMID: 1800669

Abstract

Two patients with levodopa-responsive Parkinson's syndrome had numerous cortical and striatal senile plaques and some neurofibrillary tangles at necropsy. In addition neurons in the pars compacta of the substantia nigra were severely depleted but there were no Lewy bodies or other neuropathological changes to account for parkinsonism. Neither patient was demented. These pathological findings have not previously been described as a cause of Parkinson's syndrome without associated dementia of Alzheimer's disease type.

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Selected References

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  1. Braak H., Braak E. Alzheimer's disease: striatal amyloid deposits and neurofibrillary changes. J Neuropathol Exp Neurol. 1990 May;49(3):215–224. [PubMed] [Google Scholar]
  2. Crystal H., Dickson D., Fuld P., Masur D., Scott R., Mehler M., Masdeu J., Kawas C., Aronson M., Wolfson L. Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology. 1988 Nov;38(11):1682–1687. doi: 10.1212/wnl.38.11.1682. [DOI] [PubMed] [Google Scholar]
  3. Gibb W. R., Lees A. J. The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease. Neuropathol Appl Neurobiol. 1989 Jan-Feb;15(1):27–44. doi: 10.1111/j.1365-2990.1989.tb01147.x. [DOI] [PubMed] [Google Scholar]
  4. Gibb W. R., Mountjoy C. Q., Mann D. M., Lees A. J. A pathological study of the association between Lewy body disease and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 1989 Jun;52(6):701–708. doi: 10.1136/jnnp.52.6.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Joachim C. L., Morris J. H., Selkoe D. J. Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases. Ann Neurol. 1988 Jul;24(1):50–56. doi: 10.1002/ana.410240110. [DOI] [PubMed] [Google Scholar]
  6. Katzman R., Terry R., DeTeresa R., Brown T., Davies P., Fuld P., Renbing X., Peck A. Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol. 1988 Feb;23(2):138–144. doi: 10.1002/ana.410230206. [DOI] [PubMed] [Google Scholar]
  7. Khachaturian Z. S. Diagnosis of Alzheimer's disease. Arch Neurol. 1985 Nov;42(11):1097–1105. doi: 10.1001/archneur.1985.04060100083029. [DOI] [PubMed] [Google Scholar]
  8. Mann D. M., Brown A. M., Prinja D., Jones D., Davies C. A. A morphological analysis of senile plaques in the brains of non-demented persons of different ages using silver, immunocytochemical and lectin histochemical staining techniques. Neuropathol Appl Neurobiol. 1990 Feb;16(1):17–25. doi: 10.1111/j.1365-2990.1990.tb00928.x. [DOI] [PubMed] [Google Scholar]
  9. Rudelli R. D., Ambler M. W., Wisniewski H. M. Morphology and distribution of Alzheimer neuritic (senile) and amyloid plaques in striatum and diencephalon. Acta Neuropathol. 1984;64(4):273–281. doi: 10.1007/BF00690393. [DOI] [PubMed] [Google Scholar]
  10. Sage J. I., Miller D. C., Golbe L. I., Walters A., Duvoisin R. C. Clinically atypical expression of pathologically typical Lewy-body parkinsonism. Clin Neuropharmacol. 1990 Feb;13(1):36–47. doi: 10.1097/00002826-199002000-00004. [DOI] [PubMed] [Google Scholar]
  11. Suenaga T., Hirano A., Llena J. F., Yen S. H., Dickson D. W. Modified Bielschowsky stain and immunohistochemical studies on striatal plaques in Alzheimer's disease. Acta Neuropathol. 1990;80(3):280–286. doi: 10.1007/BF00294646. [DOI] [PubMed] [Google Scholar]
  12. Tomlinson B. E., Irving D., Blessed G. Cell loss in the locus coeruleus in senile dementia of Alzheimer type. J Neurol Sci. 1981 Mar;49(3):419–428. doi: 10.1016/0022-510x(81)90031-9. [DOI] [PubMed] [Google Scholar]
  13. Wilcock G. K., Esiri M. M. Plaques, tangles and dementia. A quantitative study. J Neurol Sci. 1982 Nov;56(2-3):343–356. doi: 10.1016/0022-510x(82)90155-1. [DOI] [PubMed] [Google Scholar]
  14. Wísniewski H. M., Robe A., Zigman W., Silverman W. Neuropathological diagnosis of Alzheimer disease. J Neuropathol Exp Neurol. 1989 Nov;48(6):606–609. doi: 10.1097/00005072-198911000-00001. [DOI] [PubMed] [Google Scholar]
  15. Yamaguchi H., Hirai S., Morimatsu M., Shoji M., Ihara Y. A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by beta protein immunostaining. Acta Neuropathol. 1988;76(6):541–549. doi: 10.1007/BF00689591. [DOI] [PubMed] [Google Scholar]

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