Medical Sciences
Retraction of “Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization,” by KangAe Lee, Huafeng Zhang, David Z. Qian, Sergio Rey, Jun O. Liu, and Gregg L. Semenza, which was first published October 20, 2009; 10.1073/pnas.0909353106 (Proc. Natl. Acad. Sci. U.S.A. 106, 17910–17915).
The undersigned authors note, “We are retracting this article due to issues regarding the bottom panel of Figure 2D. Visible in this blot are the GST-HIF-1β band of interest at the top, a faint doublet in the middle, and a strong band migrating just above GST at the bottom, which is likely a degradation product of GST-HIF-1β. It appears that in the middle doublet, lanes 2, 5, and 8 are duplicate images; lanes 3, 6, and 9 are duplicate images; and lanes 4 and 7 are duplicate images. There is also concern of possible manipulation of the data shown across the bottom band. We believe that the overall conclusions of the paper remain valid, but we are retracting the work due to these underlying concerns about the figure. We apologize for the inconvenience.”
David Z. Qian, Sergio Rey, Jun O. Liu, and Gregg L. Semenza