FIG. 3.
Histopathological effects of NK1 overexpression on liver (A and B), kidney (C and D), and olfactory mucosum (E and F). NK1 liver (B) displays centrilobular hepatocellular hypertrophy not present in nontransgenic FVB/N liver (A). Renal disease in NK1 kidney (D) is characterized by tubular hyperplasia and tubular dilatation with proteinaceous casts. Control nontransgenic kidney is shown in panel C. The olfactory mucosum of NK1 mice (F) is disorganized and shows degeneration of the olfactory epithelium and hyperplasia of the olfactory glands, compared to control mice (E). All tissues were stained with hematoxylin and eosin. Magnifications, ×200 (A to D) and ×400 (E and F).