Fig. 5.
Baseline and inducible IFN-γ production by blood and hepatic MAIT cells is refractory to treatment with FOLFOX ± Avastin. PBMCs (a), tumor-free hepatic mononuclear cells (b) and tumor-infiltrating mononuclear cells (c) were isolated from CRLM patients who had received no chemotherapy (filled triangles), preoperative FOLFOX (filled circles) or FOLFOX plus Avastin (open squares). The ability of MAIT cells (left panels) and CD3+Vα7.2− conventional T cells (right panels) to produce IFN-γ in response to rIL-12+rIL-18, SEB or Klebsiella lysate was evaluated by flow cytometry. Error bars represent SEM