Table 3.
Intratumoral Tregs
Cancer | Phenotype | Associated with survival or tumor control | Reference |
---|---|---|---|
Breast cancer | IL-10+, TGF-β?? (Tr1) and CD4+CD25+Foxp3+ | Unknown (TR1), No (CD4+CD25+Foxp3+) | [13, 94] |
Ovarian cancer | CD4+CD25+ | Yes, negatively | [62, 99] |
Hodgkin’s lymphoma | IL-10 (Tr1) and Foxp3+CD4+CD25+ | Ambiguous | [97] |
Non-Hodgkin’s lymphoma | CD4+CD25+Foxp3+CTLA-4+ | Unknown | [63] |
Lung | CD4+CD25+ | Unknown | [81] |
Liver | CD4+CD25+Foxp3+TGF-β+ | No | [95, 96] |
Pancreas | IL-10+, TGF-β ??(Tr1) | Unknown | [13] |
Head and neck | CD4+CD25+ and CD4+Foxp3+ | Yes, positively | [101] |