Figure 1.
The mechanisms of MAIT cell accumulation at wound sites and their role in tissue repair. Circulating MAIT cells express various cytokine and chemokine receptors, enabling them to target and migrate to different tissues. Upon tissue damage, MAIT cells accumulate at the site of wound through chemotaxis or in-situ proliferation. The invasion of mucosal microbes or inflammatory stimuli rapidly activates MAIT cells, prompting them to secrete tissue repair factors such as IL-17, IL-22, and Areg. These cells also interact with other immune cells to facilitate the repair of damaged tissue. The dashed arrows in the Figure indicate that these processes require further experimental evidence for support. Created with Biorender.com.