Table 1. Features of V region sequences amplified from SSPE brain CD38+ population.
Group | CD38+ Vh CDR3 | Abundance | Germ line | Family | Percent ID | Vk CDR3 | Vλ CDR3 | Germ line | Family | Percent ID |
---|---|---|---|---|---|---|---|---|---|---|
1 | ALKKGEGGLRFLELYYFD | 10 | DP47 | Vh3 | 92.1 | QTWGSGMGV | Loc4b | Vλ4a | 93.7 | |
ALKKGEGGLRFLELYYFD | 3 | DP47 | Vh3 | 92.1 | ||||||
ALKKGEGGLRFLELYYLT | 1 | DP47 | Vh3 | 92.1 | QQNYSSPQT | DPK24 | Vκ4 | (t) | ||
2 | LPAAGPRSFFETYNWGMD | 8 | DP79 | Vh4 | 93.6 | AAWDDSLNAWV | DPL2 | Vλ1 | 97 | |
LPADGPRSFFETYNNGMD | 1 | DP79 | Vh4 | 93.6 | AAWDDSLNAWV | DPL2 | Vλ1 | 97 | ||
LPAAGPRSFFETYNWGMD | 1 | DP79 | Vh4 | 93.6 | ||||||
3a | IRAGAFD | 2 | DP31 | Vh3 | 95.2 | MQALQTFTF | DPK15 | Vκ2 | 99.7 | |
3b | IRAGAFD | 4 | DP31 | Vh3 | 95.2 | MQATQSWTF | DPK16 | Vκ2 | 98.2 | |
IRAGAFD | 1 | DP31 | Vh3 | 95.2 | ||||||
IRAGAFD | 1 | DP31 | Vh3 | 95.2 | (m) | |||||
4 | DFTSDSRGPLGWFD | 4 | DP79 | Vh4 | 93.9 | YSTDSSGDHRV | Loc3p | Vλ3 | 98.1 | |
DFTSDSRGPLGWFD | 1 | DP79 | Vh4 | 93.9 | ||||||
5 | GGLAARARLVLARMD | 3 | DP63 | Vh4 | 93.8 | QQSYNTPITF | DPK9 | Vκ1 | 95.1 | |
GGLAARARLVLARMD | 1 | DP63 | Vh4 | 93.8 | ||||||
6 | VRATVLTGTSMD | 2 | DP58 | Vh3 | 91.8 | GADHGSGSNFVWV | DPL22 | Vλ9 | 97.6 | |
VRATVLTGTSMD | 1 | DP58 | Vh3 | 91.8 | ||||||
7 | DTGGSGSNYYHYGMD | 2 | DP10 | Vh1 | 93.2 | |||||
DTGGSGSNYYHYGMD | 1 | DP10 | Vh1 | 93.2 | QQYNAWPPALT | DPK21 | Vκ3 | (t) | ||
8 | DRGGESDYDVGRGYSDHYGMD | 2 | DP71 | Vh4 | 86.9 | QQCGFSPKT | DPK22 | Vκ3 | 92.5 | |
9 | DQERGTILTYSDMD | 2 | DP47 | Vh3 | 95.9 | LQHNSYPHFRRR* | DPK3 | Vκ1 | 95.5 | |
10 | DQVPVNNWFD | 2 | DP14 | Vh1 | 95.2 | (m) | ||||
11 | SLTMIRGVMAFFD | 2 | DP25 | Vh1 | 87.6 | QQTYSSPSTF | DPK9 | Vκ1 | 90.9 | |
DQVIYTGWSD | 1 | DP47 | Vh3 | 91.2 | CLYAGSTTWV | DPL10 | Vλ2 | 96.3 | ||
GYYDSTGYKSAND | 1 | DP14 | Vh1 | 94.0 | QQTYSSPSTF | DPK9 | Vκ1 | 90.9 | ||
LKSRIARGSYYQYFMD | 1 | DP27 | Vh2 | 93.1 | ||||||
SADTSTAYYGLD | 1 | DP47 | Vh3 | 96.6 | LQDYNYPLTF | DPK3 | Vκ1 | 99.2 | ||
STGTDYYSYYMD | 1 | DP73 | Vh5 | 86.6 | YSTDTSGNFRV | Loc3p | Vλ3 | 99.2 | ||
EGQLALDQYYYYYMD | 1 | DP50 | Vh3 | 96.3 | NSYTSISTVV | DPL11 | Vλ2 | 93.6 | ||
DRTGYTSFLFD | 1 | DP31 | Vh3 | 90.0 | SSYAGRNKGYV | DPL12 | Vλ2 | 96 | ||
DPEEQWLADYFD | 1 | DP47 | Vh3 | 97.6 | MQATQSWTF | GTWDSSLSARV | DPL5 | Vλ1 | 98.9 | |
VEVGPNEDFYMD | 1 | DP88 | Vh1 | 90.1 | QQSYSFPWTF | DPK9 | Vκ1 | 89.4 | ||
EVAGGADIEVVPAAIGVDYHYGMD | 1 | DP79 | Vh4 | 97.3 | QSADSSGSYKV | (t) |
Each line identifies the CDR3 amino acid sequence and prevalence of each distinct H chain clone, the germ-line family, most homologous germ-line segment, percent identity to the closest germ-line segment, and the associated L chain amplification for that clone. *, an in-frame stop codon; (m), a mixed sequence that could not be further analyzed; (t), a truncated sequence.