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The normalized site-frequency spectra of noncoding, synonymous, and nonsynonymous SNPs discovered in a set of 301 human genes sequenced in 90 individuals, represented as the expected site-frequency spectra of a subsample of size 40. Nonsynonymous SNPs show a relative excess of SNPs with rare alleles. Also note the slight excess of very high-frequency variants, which we explain by ancestral misspecification.
