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. 1985 Apr 1;227(1):337–340. doi: 10.1042/bj2270337

The effect of prostaglandins E1, E2 and F2 alpha and indomethacin on the sensitivity of glycolysis and glycogen synthesis to insulin in stripped soleus muscles of the rat.

B Leighton, L Budohoski, F J Lozeman, R A Challiss, E A Newsholme
PMCID: PMC1144845  PMID: 3888199

Abstract

Prostaglandins E1 and E2 increased the sensitivity of glycolysis to insulin in the isolated stripped soleus muscle of the rat, but prostaglandin F2 alpha had no effect. Indomethacin, which inhibits prostaglandin formation, markedly decreased the sensitivity of glycolysis to insulin. These findings suggest that prostaglandins of the E series increase the sensitivity of muscle glycolysis to insulin in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Budohoski L., Challiss R. A., McManus B., Newsholme E. A. Effects of analogues of adenosine and methyl xanthines on insulin sensitivity in soleus muscle of the rat. FEBS Lett. 1984 Feb 13;167(1):1–4. doi: 10.1016/0014-5793(84)80820-0. [DOI] [PubMed] [Google Scholar]
  2. Challiss R. A., Espinal J., Newsholme E. A. Insulin sensitivity of rates of glycolysis and glycogen synthesis in soleus, stripped soleus, epitrochlearis, and hemi-diaphragm muscles isolated from sedentary rats. Biosci Rep. 1983 Jul;3(7):675–679. doi: 10.1007/BF01172878. [DOI] [PubMed] [Google Scholar]
  3. Crettaz M., Prentki M., Zaninetti D., Jeanrenaud B. Insulin resistance in soleus muscle from obese Zucker rats. Involvement of several defective sites. Biochem J. 1980 Feb 15;186(2):525–534. doi: 10.1042/bj1860525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dietze G. J. Modulation of the action of insulin in relation to the energy state in skeletal muscle tissue: possible involvement of kinins and prostaglandins. Mol Cell Endocrinol. 1982 Feb;25(2):127–149. doi: 10.1016/0303-7207(82)90047-8. [DOI] [PubMed] [Google Scholar]
  5. Dietze G., Wicklmayr M., Böttger I., Mayer L. Insulin action on glucose uptake into skeletal muscle: inhibition of endogenous biosynthesis of prostaglandins. FEBS Lett. 1978 Aug 15;92(2):294–298. doi: 10.1016/0014-5793(78)80773-x. [DOI] [PubMed] [Google Scholar]
  6. Engel P. C., Jones J. B. Causes and elimination of erratic blanks in enzymatic metabolite assays involving the use of NAD+ in alkaline hydrazine buffers: improved conditions for the assay of L-glutamate, L-lactate, and other metabolites. Anal Biochem. 1978 Aug 1;88(2):475–484. doi: 10.1016/0003-2697(78)90447-5. [DOI] [PubMed] [Google Scholar]
  7. Espinal J., Challiss R. A., Newsholme E. A. Effect of adenosine deaminase and an adenosine analogue on insulin sensitivity in soleus muscle of the rat. FEBS Lett. 1983 Jul 11;158(1):103–106. doi: 10.1016/0014-5793(83)80685-1. [DOI] [PubMed] [Google Scholar]
  8. Espinal J., Dohm G. L., Newsholme E. A. Sensitivity to insulin of glycolysis and glycogen synthesis of isolated soleus-muscle strips from sedentary, exercised and exercise-trained rats. Biochem J. 1983 May 15;212(2):453–458. doi: 10.1042/bj2120453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Flower R. J. Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev. 1974 Mar;26(1):33–67. [PubMed] [Google Scholar]
  10. Reeds P. J., Palmer R. M. Changes in prostaglandin release associated with inhibition of muscle protein synthesis by dexamethasone. Biochem J. 1984 May 1;219(3):953–957. doi: 10.1042/bj2190953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Reeds P. J., Palmer R. M. The possible involvement of prostaglandin F2 alpha in the stimulation of muscle protein synthesis by insulin. Biochem Biophys Res Commun. 1983 Nov 15;116(3):1084–1090. doi: 10.1016/s0006-291x(83)80253-8. [DOI] [PubMed] [Google Scholar]
  12. Rodemann H. P., Goldberg A. L. Arachidonic acid, prostaglandin E2 and F2 alpha influence rates of protein turnover in skeletal and cardiac muscle. J Biol Chem. 1982 Feb 25;257(4):1632–1638. [PubMed] [Google Scholar]
  13. Wieser P. B., Fain J. N. Insulin, prostaglandin E1, PHENYLISOPROPYLADENOSINE AND NICOTINIC ACID AS REGULATORS OF FAT CELL METABOLISM. Endocrinology. 1975 May;96(5):1221–1225. doi: 10.1210/endo-96-5-1221. [DOI] [PubMed] [Google Scholar]
  14. Willebrands A. F., Tasseron S. J. Effect of hormones on substrate preference in isolated rat heart. Am J Physiol. 1968 Nov;215(5):1089–1095. doi: 10.1152/ajplegacy.1968.215.5.1089. [DOI] [PubMed] [Google Scholar]

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