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. 2024 Nov 13;19(11):e0313921. doi: 10.1371/journal.pone.0313921

Retraction: Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

The PLOS ONE Editors
PMCID: PMC11560023  PMID: 39536040

After publication of the Expression of Concern on this article [1, 2], additional concerns were raised about results presented in Figs 7 and 8. Specifically, in Figs 7Biv, 8A and 8C in this article, a number of further blots and/or bands appear similar to each other across two or more figure panels. Some blots and/or bands in these figures of [1] also appear similar to images in Figs 2 and 4 in [3].

The authors have not provided the underlying data that support the published results. As such PLOS cannot resolve the concerns about the similarities between the articles [1, 3, 4] summarized above and in the Expression of Concern [2] and so the PLOS ONE Editors retract this article.

All authors either did not respond directly or could not be reached.

References

  • 1.Braidy N, Guillemin GJ, Mansour H, Chan-Ling T, Poljak A, Grant R (2011) Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats. PLoS ONE 6(4): e19194. 10.1371/journal.pone.0019194 [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
  • 2.The PLOS ONE Editors (2022) Expression of Concern: Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats. PLoS ONE 17(1): e0263555. 10.1371/journal.pone.0263555 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Braidy N., Poljak A., Grant R. et al. (2014) Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology 15, 177–198. 10.1007/s10522-013-9489-5 [DOI] [PubMed] [Google Scholar]
  • 4.Braidy N, Poljak A, Grant R, Jayasena T, Mansour H, Chan-Ling T, Smythe G, Sachdev P and Guillemin GJ (2015) Differential expression of sirtuins in the aging rat brain. Front. Cell. Neurosci. 9:167. 10.3389/fncel.2015.00167 [DOI] [PMC free article] [PubMed] [Google Scholar]

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