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Effect of TBH treatment on protein binding to the rat GCLC AP-1 site in vivo. ChIP assay was used to assess transcription factor binding to the AP-1 site of rat GCLC in an endogenous chromatin configuration as described in Materials and Methods. Note that TBH treatment increased c-Jun, c-Fos, and Fra-1 binding to the rat GCLC AP-1 site. Nrf2 does not bind to this site, but increased binding to the ARE site of mouse GCLM can be seen following TBH treatment.
