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. 2003 Dec 15;74(1):106–120. doi: 10.1086/381000

Table 1.

Comparison of SNPs at Different Frequencies and Thresholds in Two Populations

African Americans
 European Americans
No. of
 No. of
tagSNPs at
 tagSNPs at
Gene GenBank Accession Numbera No. ofBase Pairs Scanned Nucleotide Diversity(π×10-4) SNPs Common SNPs r2>0.5 r2>0.8 Nucleotide Diversity(π×10-4) SNPs Common SNPs r2>0.5 r2>0.8
ACE AY436326 22,122 9.22 83 44 11 21 6.31 43 27 2 5
AGT AY436323 15,593 12.97 91 43 6 16 13.51 84 52 6 10
AGTR1 AY436325 45,926 11.67 253 95 29 42 7.14 128 74 10 18
APOB AY324608 44,547 5.31 159 43 12 20 3.77 79 32 7 11
BDKRB2 AF378542 14,050 6.68 61 19 8 12 7.00 49 22 5 9
BF AF551848 9,956 5.92 30 11 6 6 5.30 26 6 3 4
CCR2 AF545480 10,073 6.75 41 12 5 8 5.85 22 19 6 7
CD36 AY095373 29,921 9.79 167 49 12 25 7.16 80 35 5 8
CEBPB AY193834 4,508 7.22 13 6 3 3 4.70 10 3 1 2
CRF AF410771 9,293 7.99 38 16 11 15 7.21 24 14 4 6
CRP AF449713 6,715 10.51 30 14 4 7 5.05 13 5 3 3
CSF2 AF373868 5,992 11.24 30 9 4 7 6.68 17 9 2 3
CSF3 AF388025 5,527 8.91 28 4 1 2 8.62 17 8 2 2
CSF3R AY148100 18,843 9.60 99 29 9 13 6.17 52 23 3 10
DCN AF491944 34,947 8.06 141 38 9 14 1.20 40 8 5 5
F10 AF503510 28,937 6.42 98 33 20 27 5.01 63 28 13 18
F11 AY191837 26,603 8.87 120 51 11 22 6.65 63 41 6 10
F12 AF538691 10,616 6.12 44 10 7 8 4.17 22 10 4 6
F2 AF478696 20,407 5.93 90 15 5 10 4.78 57 8 2 5
F2R AF391809 24,231 6.96 94 34 10 13 5.36 52 28 6 12
F2RL1 AF400075 17,715 7.36 98 19 4 7 6.41 43 24 5 8
F2RL2 AF374726 9,273 13.42 61 24 8 12 11.82 37 22 6 7
F2RL3 AF384819 10,214 7.27 42 19 6 12 6.60 25 16 3 6
F3 AF540377 16,114 6.57 61 19 9 12 5.41 26 19 4 6
FGA AF361104 9,947 3.99 23 6 3 5 3.18 17 5 3 3
FGB AF388026 11,604 4.56 45 7 4 4 7.93 36 24 3 3
FGG AF350254 10,168 3.49 21 7 4 4 2.28 12 6 3 3
FGL2 AF468959 6,382 4.14 19 5 4 4 2.78 6 2 2 2
FSBP AF487652 9,846 5.96 31 11 3 5 5.01 26 12 4 5
GP1BA AF395009 6,241 8.23 27 9 6 6 7.67 21 8 3 4
HMGCR AY321356 27,810 3.61 69 17 4 7 4.08 49 20 2 4
ICAM1 AY225514 17,731 6.08 61 19 10 13 5.28 39 19 7 10
IFNG AF375790 7,665 4.87 28 5 5 5 4.62 13 7 2 4
IL10 AF418271 7,879 9.32 26 13 2 3 9.66 24 17 4 4
IL10RA AY195619 19,942 7.00 69 31 7 14 5.17 49 16 2 7
IL11 AY207429 8,964 9.85 40 17 11 14 7.30 24 15 4 6
IL12A AF404773 11,330 9.65 52 21 6 9 7.88 29 23 4 4
IL12B AF512686 14,902 7.86 52 19 5 6 5.95 33 23 6 6
IL13 AF377331 6,919 8.62 27 12 7 12 4.46 16 6 2 3
IL17B AF386077 9,077 4.85 32 7 2 4 7.28 22 15 3 3
IL19 AF390905 10,998 7.14 43 13 4 5 4.18 24 8 1 2
IL1A AF536338 17,849 9.57 78 38 4 7 10.99 50 44 3 4
IL1B AY137079 17,447 5.54 51 21 8 15 4.45 35 17 3 7
IL1R1 AF531102 27,864 7.91 134 38 15 24 7.21 85 40 7 15
IL1R2 AY124010 23,160 16.00 188 85 12 23 10.20 101 80 5 7
IL1RN AY196903 19,677 11.59 146 37 11 16 13.19 91 69 5 11
IL2 AF359939 6,752 3.79 20 3 2 2 3.57 10 5 3 4
IL20 AF402002 6,634 6.91 25 7 6 6 4.73 17 5 2 4
IL21R AY064474 25,844 8.52 116 35 15 21 7.34 76 36 8 17
IL22 AF387519 8,393 10.04 46 12 5 10 9.62 28 18 4 5
IL24 AY062931 10,628 7.56 41 16 5 6 6.50 24 14 3 3
IL2RB AF517934 26,029 13.31 148 66 28 42 10.65 100 59 15 18
IL3 AF365976 6,387 5.47 27 6 5 5 3.07 9 4 2 3
IL4 AF395008 22,845 9.53 105 45 14 29 4.80 56 25 5 6
IL4R AF421855 25,917 16.21 179 78 20 38 11.69 118 58 8 18
IL5 AF353265 5,186 5.14 16 4 2 3 0.92 3 1 1 1
IL6 AF372214 7,526 8.80 41 10 4 6 9.14 26 12 3 6
IL8 AF385628 7,035 6.89 35 9 5 5 4.66 9 7 1 1
IL9 AF361105 6,676 6.40 28 8 3 6 3.64 14 7 2 2
IRAK4 AY186092 33,033 7.87 153 34 5 14 3.15 72 5 2 4
JAK3 AF513860 19,067 12.46 113 48 21 27 7.62 56 31 9 14
KEL AY228336 25,850 9.38 128 50 12 22 1.47 47 2 1 2
KLK1 AY094609 9,922 12.93 63 24 7 14 13.00 46 27 5 6
KLKB1 AY190920 31,670 12.53 165 74 13 27 12.95 128 88 8 14
LDL AY324609 42,873 7.87 178 60 27 38 7.29 109 65 7 17
LTA AY070490 5,033 9.54 20 10 6 6 11.48 19 14 5 8
LTB AY070219 4,412 3.84 16 2 1 1 2.07 7 2 1 1
MC1R AF514787 6,545 12.06 36 14 6 8 9.55 22 11 2 4
MMP3 AF405705 11,904 8.85 50 17 5 9 7.56 35 16 3 4
NOS3 AF519768 23,307 7.95 102 33 16 21 6.41 54 34 11 13
PLAU AF377330 9,274 8.87 30 17 4 6 7.52 23 13 1 3
PLAUR AY194849 23,187 12.47 166 44 21 29 7.99 94 18 8 11
PON1 AF539592 29,052 14.02 175 89 28 44 8.80 121 55 11 25
PON2 AY210982 32,487 9.13 137 60 10 20 8.94 101 72 7 13
PROC AF378903 12,877 9.09 52 25 5 12 10.18 39 28 3 7
PROCR AF375468 6,968 5.37 15 9 3 3 6.10 14 8 2 2
PROZ AF440358 14,366 8.63 86 24 11 15 8.04 46 27 2 3
REN AY436324 13,640 11.52 78 28 15 24 6.67 46 16 3 7
SCYA2 AF519531 9,070 7.66 38 15 9 10 6.79 25 14 6 8
SELE AF540378 13,892 11.20 86 25 6 9 9.83 70 20 5 9
SELP AF542391 43,454 10.50 254 72 14 34 8.20 141 64 11 18
SERPINA5 AF361796 7,806 18.68 61 29 8 11 17.84 41 25 7 4
SERPINC1 AF386078 15,208 6.19 43 18 6 12 3.21 27 13 1 10
SERPINE1 AF386492 13,208 11.13 85 25 7 11 9.68 48 27 6 8
SFTPA1 AY198391 23,126 15.28 170 71 10 21 9.68 153 29 7 10
SFTPA2 AY206682 18,039 16.95 152 60 22 30 8.34 111 23 6 12
SFTPB AF400074 11,094 9.42 49 21 7 9 4.55 18 11 6 7
SFTPD AY216721 23,538 12.17 151 42 12 20 13.68 134 51 4 10
SMP1 AF458851 25,269 6.93 90 37 6 9 3.40 39 12 2 2
STAT6 AF417842 18,769 4.30 53 13 6 10 2.89 22 12 4 6
TGFB3 AY208161 23,236 7.24 81 32 10 21 4.82 50 24 3 4
THBD AF495471 7,254 4.10 24 6 4 4 2.79 14 4 3 3
TNFAIP1 AY065346 14,331 4.79 53 10 5 5 2.39 19 6 3 3
TNF AY066019 4,830 4.71 21 2 1 1 3.72 12 2 1 2
TNFRSF1A AY131997 16,207 7.44 60 26 13 17 4.80 26 14 2 4
TRPV5 AY206695 29,555 12.41 180 69 8 18 2.15 66 9 1 1
TRPV6 AY225461 27,629 14.24 142 74 9 18 1.16 63 1 1 1
VCAM1 AF536818 22,868 6.55 102 24 13 14 3.93 39 21 8 11
VEGF AF437895 15,442 8.95 64 26 11 20 9.21 49 25 8 10
VTN AF382388 5,559 10.59 28 11 3 4 5.29 15 4 1 2
a

Polymorphisms identified in these GenBank records by the SeattleSNPs PGA or the Pharmacogenetics and Risk of Cardiovascular Disease project were included in the analysis.