Table 1.
Sample Characteristics Using the Restricted and Broad Diagnostic Criteria (Genotyped Individuals Only)
|
Using Restricted Diagnostic Criteria (R-AMD) |
Using Broad Diagnostic Criteria (B-AMD) |
|||||||
| Characteristic | AMD | GA | CNV | GA or CNV | AMD | GA | CNV | GA or CNV |
| No. (%) of affected individuals | 274 (100) | 95 (35) | 133 (49) | 190 (69) | 331 (100) | 102 (31) | 134 (40) | 195 (59) |
| No. (%) of affected females | 184 (67) | 61 (64) | 91 (68) | 128 (67) | 221 (67) | 65 (64) | 91 (68) | 130 (67) |
| No. of families with: | ||||||||
| ⩾1 affected individual | 113 | 64 | 89 | 105 | 113 | 65 | 89 | 105 |
| ⩾2 affected individuals | 93 | 19 | 28 | 56 | 113 | 22 | 28 | 57 |
| ⩾3 affected individuals | 35 | 7 | 12 | 18 | 47 | 7 | 12 | 18 |
| Affected individuals per family with ⩾2 affected individuals | 2.73 | 2.63 | 2.57 | 2.52 | 2.9 | 2.7 | 2.6 | 2.6 |
| Average age at diagnosis: | ||||||||
| Mean (stdev) | 70.2 (9.2) | 68.4 (10.2) | 70.5 (9.2) | 69.8 (9.5) | 70.3 (9.1) | 68.7 (10.2) | 70.5 (9.2) | 69.8 (9.5) |
| Median (Q1−Q3) | 71.0 (64.0−76.0) | 70.0 (61.0−75.0) | 71.0 (65.0−76.0) | 71.0 (63.5−76.0) | 71.0 (64.0−76.0) | 70.0 (61.0−76.0) | 71.0 (65.0−76.0) | 71.0 (63.5−76.0) |
| Average age at last examination: | ||||||||
| Mean (stdev) | 79.0 (7.6) | 80.2 (7.1) | 79.4 (7.6) | 79.5 (7.5) | 78.2 (7.9) | 80.3 (7.2) | 79.5 (7.6) | 79.6 (7.5) |
| Median (Q1−Q3) | 79.2 (74.3−84.4) | 80.8 (74.8−86.1) | 79.8 (74.4−84.1) | 79.8 (74.8−84.7) | 78.6 (73.6−84.0) | 80.9 (74.9−86.1) | 79.8 (74.5−84.1) | 79.8 (74.8−84.8) |