Table 1.
Effects of amino acid substitutions on aggregation of Aβ (Alzheimer) peptide
| Proposed interactions between β-strands | Substitution | Effect of substitution |
|---|---|---|
| Lys-16–Glu-23 | Lys→Ala | no β-sheets at any pH |
| His-14–Val-24 | His→Ala | increased fibre formation |
| His-14–Val-24 | His→Asp | stabilises fibres at pH 2.5 |
| no β-sheets at pH 7.8 | ||
| Glu-11–Arg-5 | Glu→Ala | reduced interaction with wild type |
| Val-18-–Phe-20 | Val→Lys | reduced interaction with wild type |
| Arg-5–Glu-11 | Arg→Glu | no interaction with wild type |
| His-13–Glu-3 | His→Leu | reduced interaction with wild type |