Table 1.
Characteristics of the population according to MTHFR genotype
| C/C (n = 187) | T/T (n = 105) | P value | |
|---|---|---|---|
| Age | 59.77 ± 9.96 | 59.92 ± 11.39 | N.S. |
| Sex, % male | 80.21 | 77.14 | N.S.* |
| Plasma folate, nmol/liter | 12.71 (9.81–11.96) | 10.42 (9.58–11.33) | <0.0001 |
| RBC folate, nmol/g Hb | 1267.49 ± 684.28 | 833.55 ± 435.84 | <0.0001 |
| Vitamin B12, pmol/liter | 297 (280–315) | 292 (274–316) | N.S. |
| Vitamin B6, nmol/liter | 30.38 (27.93–33.04) | 33.85 (30.17–37.97) | N.S. |
| tHcy, μmol/liter | 14.70 (13.90–15.54) | 21.26 (19.64–22.98) | <0.0001 |
| Genomic DNA methylation status, ng mCyt/μg DNA | 62.24 (54.32–71.31) | 32.23 (24.78–41.92) | <0.0001 |
Values are expressed as mean ± SD for age and RBC folate. Plasma folate, vitamin B12, vitamin B6, tHcy, and DNA methylation status are presented as geometric means (antilogarithms of the transformed means) and 95% confidence intervals are reported in parentheses with two-tailed P values. Statistical difference was evaluated by Student's t test except when differently indicated. N.S., not statistically significant.
*
Statistical difference was evaluated by χ2 test.