Table 1.
Analysis of in vivo cardiac size and function by echocardiography in wild-type and cav-1 knockout mice
| LVEDD, mm | LVESD, mm | % FS | SEPth, mm | PWth, mm | Mean VCF, cir/s | BW, g | Age, day | |
|---|---|---|---|---|---|---|---|---|
| cav-1+/+ (n = 6) | 3.25 ± 0.07 | 1.68 ± 0.13 | 48.5 ± 3.6 | 0.71 ± 0.04 | 0.73 ± 0.03 | 9.71 ± 1.14 | 30.4 ± 1.6 | 143 ± 3 |
| cav-1−/− (n = 7) | 3.97 ± 0.19 | 2.63 ± 0.24 | 34.6 ± 3.2 | 0.60 ± 0.03 | 0.61 ± 0.02 | 6.23 ± 0.51 | 29.5 ± 1.6 | 140 ± 4 |
Echocardiography was performed in anesthetized age- and gender-matched mice. LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; %FS, percent fractional shortening calculated as %FS = [(EDD − ESD)/EDD] × 100; SEPth, intraventricular septal wall thickness; PWth, left ventricular posterior wall thickness; mean VCF, heart-rate-corrected mean velocity of circumferential fiber shortening; BW, body weight. Data are expressed as mean ± SEM.
*
, P < 0.05.