Table II. Transgenic rescue of GATA-1.05 mutant mice from embryonic lethality.
| Construct | Expression level | No. of pups | X/Y::transgene (−) |
X/Y::transgene (+) |
GATA-1.05/Y::transgene (−) | GATA-1.05/Y::transgene (+) | ||
|---|---|---|---|---|---|---|---|---|
| Observed | Expected | Observed | Expected | |||||
| Wild type | high | 43 | 4 | 4 | 6 | 0 | 3 | 6 |
| low | 47 | 12 | 7 | 7 | 0 | 7 | 7 | |
| ΔNF | medium | 125 | 19 | 15 | 18 | 0 | 0 | 18 |
| low | 17 | 3 | 1 | 2 | 0 | 0 | 2 | |
| ΔCF | high | 59 | 11 | 9 | 8 | 0 | 0 | 8 |
| medium | 31 | 5 | 5 | 4 | 0 | 0 | 4 | |
| ΔNT | high | 111 | 16 | 14 | 16 | 0 | 15 | 16 |
| medium | 152 | 22 | 24 | 22 | 0 | 6 | 22 | |
| low | 48 | 8 | 6 | 7 | 0 | 1 | 7 | |
| ΔNTNF | high | 35 | 6 | 6 | 5 | 0 | 0 | 5 |
| medium | 74 | 14 | 13 | 11 | 0 | 0 | 11 | |
| low | 45 | 10 | 9 | 6 | 0 | 0 | 6 | |