Table I. Distribution of the ideS gene and IdeS enzyme activity during S.pyogenes growth in TH medium supplemented with human IgG.
| Strain | M-serotype | Reference or source | IgG cleavage (in the presence of E64) | PCR product |
|---|---|---|---|---|
| SF370 | 1 | Suvorov and Feretti (1996); Ferretti et al. (2001) | (+) | + |
| AP1 | 1 | WHO Prague collectiona | + | + |
| AL1 | 1 | speB mutant of AP1; Collin and Olsén (2001a) | + | n.d.b |
| BMJ71 | 1 | mga mutant of AP1; Kihlberg et al. (1995) | + | n.d. |
| KTL3 | 1 | Finnish institute for health | (+) | + |
| AP4 | 4 | WHO Prague collection | – | + |
| M5 | 5 | sequencing in progessc | – | + |
| AP6 | 6 | WHO Prague collection | – | + |
| AP12 | 12 | WHO Prague collection | + | + |
| AP49 | 49 | WHO Prague collection | – | + |
| AP53 | 53 | WHO Prague collection | – | + |
| AP55 | 55 | WHO Prague collection | + | + |
| AP57 | 57 | WHO Prague collection | – | + |
aWHO Collaborating Center for Reference and Research on Streptococci, Institute of Hygiene and Epidemiology, Prague, Czech Republic.
bn.d., not determined.
cSanger Center in collaboration with Dr Michael Kehoe, University of Newcastle, UK.
+, indicates weak activity.