TABLE 1.
Isotypes of A. fumigatus-specific serum antibodies 22 days postinfection
| Antigen | Presence or absence of the following isotype in seruma:
|
||||||
|---|---|---|---|---|---|---|---|
| IgG | IgG3 | IgG1 | IgG2b | IgG2a | IgE | IgA | |
| Mice infected with live conidia | |||||||
| Hyphae | +++ | − | +++ | +++ | +++ | − | ++ |
| Asp f 2 | +++ | − | +++ | +++ | +++ | − | +++ |
| Asp f 3 | +++ | + | +++ | +++ | ++ | − | + |
| HIC-challenged mice | |||||||
| Hyphae | − | − | − | − | − | − | − |
| Asp f 2 | − | − | − | − | − | − | − |
| Asp f 3 | − | − | − | − | − | − | − |
a
+++, all mice tested had serum antibodies with an absorbance of >1 at a 1:50 dilution; ++, three out of four mice had serum antibodies with an absorbance of >1 at a 1:50 dilution; +, one out of four mice had serum antibodies with an absorbance of >1 at a 1:50 dilution; −, all mice tested had serum antibodies with an absorbance of <0.2 at a 1:50 dilution.