TABLE 3.
Course of experimental bacterial infections in mice with disrupted LTβR signaling
| Pathogen | LT/TNF ligand/receptor−/− mouse/inhibitor | Outcome | Reference |
|---|---|---|---|
| Mycobacterium bovis BCG | BALB/c wt treated with LTβRIgG/human IgG | Reduced number of splenic granulomas, splenic eosinophil infiltrate, higher bacterial burden in LTβRIgG-treated mice | 39 |
| TNF/LTα−/− | Increased bacterial burden, lethal course of infection, impaired and delayed granuloma formation | 26 | |
| TNF/LTα−/−, TNF/LTα−/− LTα+/+ transgenic, LTα−/− | Lethal course of disease with pulmonary necrosis and increased bacterial burden in TNF/LTα−/− mice; prolonged survival in LTα+/+ transgenic TNF/LTα−/− mice; resistance to LPS-induced shock in TNF/LTα−/− mice | 8 | |
| Transgenic transmembrane TNF+/+ expression in TNF/LTα−/− mice, TNF/LTα−/−, TNF-α−/−, LTα−/− | TNF/LTα−/− mice with transgenic membrane TNF expression control mycobacterial infection with higher bacterial burden than in wt mice; TNF/LTα−/−, TNFα−/−, LTα−/− mice succumb | 51 | |
| Mycobacterium tuberculosis | LTα−/− → RAG1−/− bone marrow chimera | Lethal course of infection, formation of enlarged granulomas | 58 |
| LTβ−/− → RAG1−/− bone marrow chimera | Clearing of infection at the same rate as wt mice | ||
| LTα−/−, LTβ−/−, LTβR−/−, LIGHT−/− | LTα−/−, LTβ−/−, higher bacterial loads in lungs and livers; LTβR−/−, lethal course of infection, formation of enlarged granuloma; LIGHT−/−, clearing of infection at the same rate as wt mice | 14 | |
| Listeria monocytogenes | TNF/LTα−/− | Lethal course of infection, higher bacterial burden in liver and spleen, hepatic necrosis | 17 |
| LTβR−/− | Lethal course of infection | 14 | |
| Salmonella enterica serovar Typhimurium | TNF/LTα−/− | Resistance to lethal LPS challenge, lethal course of infection, higher organ bacterial load | 12 |
| Salmonella enterica | LTβR−/− | Course of colitis induced following streptomycin or water treatment is similar in wt and LTβR−/− mice | 4 |
| Citrobacter rodentium | LTα−/−, LTβ−/−, LTβR−/−, LTβRIgG-treated | Lethal course of infection in all LT ligand/receptor gene-deficient mice with spread of bacteria to liver and spleen; more severe course in LTβRIgG-treated wt mice | 65 |