Table 1.
Summary of SCID mice subcutaneous tumor injection experiments
| Cell lines | No. sites injected | No. tumors formed | Time to form tumors to 0.5 cm size | Significance |
|---|---|---|---|---|
| Parental G5 m/Terc−/−Wrn−/−#1 P1 | 4 | 0 | n.a. | |
| Parental G5 m/Terc−/−Wrn−/−#2 P2 | 8 | 0 | ||
| Parental G5 m/Terc−/−Wrn−/−#3 P1 | 4 | 0 | ||
| Immortalized G5 m/Terc−/−Wrn−/− + vector #1 P2 | 8 | 8 | 43 d | |
| Immortalized G5 m/Terc−/−Wrn−/− + vector #2 P2 | 8 | 6 | 42 d | |
| Immortalized G5 m/Terc−/−Wrn−/− + vector #3 P3 | 8 | 6 | 48 d | |
| Immortalized G5 m/Terc−/−Wrn−/− + vector #4 P5 | 8 | 4 | 41 d | |
| P < 0.004 | ||||
| Immortalized G5 m/Terc−/−Wrn−/− + H-Ras #1 P2 | 4 | 4 | 25 d | |
| Immortalized G5 m/Terc−/−Wrn−/− + H-Ras #2 P2 | 4 | 2 | 26 d | |
| Immortalized G5 m/Terc−/−Wrn−/− + H-Ras #3 P3 | 4 | 4 | 20 d | |
| P < 0.01 | ||||
| Immortalized G5 m/Terc−/−Wrn++ p53−/− #1 P3 | 4 | 0 | n.a. | |
| Immortalized G5 m/Terc−/−Wrn++ p53−/− #2 P4 | 8 | 0 |
(n.a.) Not applicable. P values were determined by Wilcoxon two-sided ranks test analysis.