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Pharmacological reversal of hyperexcitability in area CA3 by K252a. A, Responses recorded in the pyramidal cell layer of area CA3 to paired hilar stimuli are shown. Before bath application of K252a, multiple population spikes occurred after five paired stimuli at 1 Hz (arrows). B, After K252a perfusion for 60 min, the same stimuli shown in A only evoked one population spike per stimulus.
