Table 1.
List of all possible meiotic types, and their probabilities, for analysis of a disease locus (D) and two linked marker loci (M1, M2), for the alternative hypothesis of linkage (top) and the null hypothesis of no linkage (bottom).
|
Recombination Status in Interval (locus orderM1-(x, D)-M2) |
||||
| Meiotic Type | M1-x | x-M2 | x-D | Probability |
| Y1 | N | N | N | (1-ε)[1-θx1)(1-θx2)] |
| Y2 | N | R | N | (1-ε)[(1-θx1)θx2] |
| Y3 | R | N | N | (1-ε)[θx1(1-θx2)] |
| Y4 | R | R | N | (1-ε)[θx1θx2] |
| Y5 | N | N | R | ε[(1-θx1)(1-θx2)] |
| Y6 | N | R | R | ε[(1-θx1)θx2] |
| Y7 | R | N | R | ε[θx1(1-θx2)] |
| Y8 | R |
R |
R |
ε[θx1θx2] |
|
Recombination Status in Interval (locus order D…M1-(x)-M2; θD1=0.5) |
||||
| D–M1 |
M1–x |
x–M2 |
||
| Y1 | N | N | N | 0.5[(1-θx1)(1-θx2)] |
| Y2 | N | N | R | 0.5[(1-θx1)θx2] |
| Y3 | R | R | N | 0.5[θx1(1-θx2)] |
| Y4 | R | R | R | 0.5[θx1θx2] |
| Y5 | R | N | N | 0.5[(1-θx1)(1-θx2)] |
| Y6 | R | N | R | 0.5[(1-θx1)θx2] |
| Y7 | N | R | N | 0.5[θx1(1-θx2)] |
| Y8 | N | R | R | 0.5[θx1θx2] |