Table 2.
Error Rates When Parents Are Available
|
Error
Rateb When
Total No. of Offspring
Is |
|||||
| Offspring per Family and Test Casea | 120 | 240 | 480 | 960 | 1,920 |
| 1: | |||||
| Overall | 5.5 | 5.3 | 5.4 | 5.1 | 5.1 |
| 2: | |||||
| Null | 5.4 | 5.0 | 5.3 | 4.8 | 5.0 |
| Admixture | 5.6 | 5.4 | 5.4 | 4.6 | 5.7 |
| Sibling resemblance | 4.8 | 5.0 | 4.7 | 4.4 | 5.2 |
| Linkage | 7.0 | 5.4 | 5.7 | 5.0 | 5.3 |
| Composite | 5.6 | 4.8 | 4.9 | 5.4 | 5.1 |
| 4: | |||||
| Null | 5.1 | 5.1 | 4.9 | 4.5 | 4.2 |
| Admixture | 5.0 | 4.9 | 4.5 | 5.2 | 4.7 |
| Sibling resemblance | 4.8 | 5.0 | 4.7 | 4.4 | 4.8 |
| Linkage | 7.0 | 5.4 | 5.7 | 5.0 | 5.2 |
| Composite | 5.6 | 4.8 | 4.9 | 5.4 | 5.3 |
| 8: | |||||
| Null | 4.9 | 5.3 | 5.7 | 4.8 | 5.5 |
| Admixture | 4.5 | 4.4 | 4.9 | 4.2 | 5.2 |
| Sibling resemblance | 4.4 | 4.0 | 4.5 | 4.7 | 4.8 |
| Linkage | 6.5 | 6.2 | 5.9 | 5.8 | 6.1 |
| Composite | 5.2 | 5.3 | 5.0 | 5.2 | 4.7 |
a
Null = no sibling resemblance, or major-gene effect (s2=h2=0); Admixture = no sibling resemblance, or major-gene effect (s2=h2=0, with population admixture); Sibling resemblance = large sibling resemblance (s2=.5); Linkage = linked major gene of large effect (h2=.3, θ=0); Composite = composite test case (s2=.3 and h2=.2, θ=0). There was no linkage disequilibrium between QTL and marker locus (D=0). For single-child families, only the overall error rate is reported. Each estimate is based on 5,000 replicates.
b
Shown as the proportion of simulations exceeding the nominal significance level, .05.