Skip to main content
NCBI home page
Journal of the Royal Society of Medicine logoLink to Journal of the Royal Society of Medicine
. 1987 Feb;80(2):91–93. doi: 10.1177/014107688708000210

Effectiveness of amantadine in reducing relapses in multiple sclerosis.

G S Plaut
PMCID: PMC1290678  PMID: 3550084

Abstract

Fifty-three patients with multiple sclerosis were assessed in a double-blind multicentre study for the effect of amatadine. The patients were observed in general practices for up to four years. Relapses occurred in 5 of the 24 patients treated with amantadine and in 14 of the 29 placebo-treated patients. Neurological deterioration was not significantly different in the two groups.

Full text

PDF
91

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abb J., Deinhardt F., Zander H., Tenser R. B., Rapp F., Goust J. M., Fudenberg H. H., Vilcek J., Ho M., Merigan T. C. Infectious Diseases Society of America. Trials of interferon therapy for multiple sclerosis. J Infect Dis. 1982 Jul;146(1):109–115. doi: 10.1093/infdis/146.1.109. [DOI] [PubMed] [Google Scholar]
  2. Acheson E. D. Epidemiology of multiple sclerosis. Br Med Bull. 1977 Jan;33(1):9–14. doi: 10.1093/oxfordjournals.bmb.a071407. [DOI] [PubMed] [Google Scholar]
  3. Barnes M. P., Bates D., Cartlidge N. E., French J. M., Shaw D. A. Hyperbaric oxygen and multiple sclerosis: short-term results of a placebo-controlled, double-blind trial. Lancet. 1985 Feb 9;1(8424):297–300. doi: 10.1016/s0140-6736(85)91079-7. [DOI] [PubMed] [Google Scholar]
  4. Carp R. I., Licursi P. C., Merz P. A., Merz G. S. Decreased percentage of polymorphonuclear neutrophils in mouse peripheral blood after inoculation with material from multiple sclerosis patients. J Exp Med. 1972 Sep 1;136(3):618–629. doi: 10.1084/jem.136.3.618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Clinical immunology. Lancet. 1976 Aug 28;2(7983):450–451. [PubMed] [Google Scholar]
  6. Douglas A. P., Hamlyn A. N., James O. Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning. Lancet. 1976 Jan 17;1(7951):111–115. doi: 10.1016/s0140-6736(76)93154-8. [DOI] [PubMed] [Google Scholar]
  7. Dowling S. J. Lourdes cures and their medical assessment. J R Soc Med. 1984 Aug;77(8):634–638. doi: 10.1177/014107688407700803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ebers G. C., Paty D. W., Stiller C. R., Nelson R. F., Seland T. P., Larsen B. HLA-typing in multiple sclerosis sibling pairs. Lancet. 1982 Jul 10;2(8289):88–90. doi: 10.1016/s0140-6736(82)91702-0. [DOI] [PubMed] [Google Scholar]
  9. Field E. J., Joyce G. Screening of children at risk of multiple sclerosis. Lancet. 1977 Jul 16;2(8029):141–141. doi: 10.1016/s0140-6736(77)90153-2. [DOI] [PubMed] [Google Scholar]
  10. Galbraith A. W. Influenza--recent developments in prophylaxis and treatment. Br Med Bull. 1985 Oct;41(4):381–385. doi: 10.1093/oxfordjournals.bmb.a072080. [DOI] [PubMed] [Google Scholar]
  11. Galbraith A. W. Prevention of post-herpetic neuralgia by amantadine hydrochloride (Symmetrel). Br J Clin Pract. 1983 Sep;37(9):304–306. [PubMed] [Google Scholar]
  12. Gay D., Dick G., Upton G. Multiple sclerosis associated with sinusitis: case-controlled study in general practice. Lancet. 1986 Apr 12;1(8485):815–819. doi: 10.1016/s0140-6736(86)90936-0. [DOI] [PubMed] [Google Scholar]
  13. Gore M., Buckman R., Stern G. Intrathecal cytarabine in multiple sclerosis. Lancet. 1979 Jul 28;2(8135):204–204. doi: 10.1016/s0140-6736(79)91476-4. [DOI] [PubMed] [Google Scholar]
  14. James W. H. Concordance in twins and recurrence in sibships of multiple sclerosis. Lancet. 1982 Mar 20;1(8273):690–690. [PubMed] [Google Scholar]
  15. KURTZKE J. F. On the evaluation of disability in multiple sclerosis. Neurology. 1961 Aug;11:686–694. doi: 10.1212/wnl.11.8.686. [DOI] [PubMed] [Google Scholar]
  16. Kurtzke J. F., Hyllested K. Multiple sclerosis in the Faroe Islands. II. Clinical update, transmission, and the nature of MS. Neurology. 1986 Mar;36(3):307–328. doi: 10.1212/wnl.36.3.307. [DOI] [PubMed] [Google Scholar]
  17. Malone P. R., Stanton S. L., Riddle P. R. Urinary diversion for incontinence--a beneficial procedure? Ann R Coll Surg Engl. 1985 Nov;67(6):349–352. [PMC free article] [PubMed] [Google Scholar]
  18. McDonald W. I. The mystery of the origin of multiple sclerosis. J Neurol Neurosurg Psychiatry. 1986 Feb;49(2):113–123. doi: 10.1136/jnnp.49.2.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Mertin J., Rudge P., Kremer M., Healey M. J., Knight S. C., Compston A., Batchelor J. R., Thompson E. J., Halliday A. M., Denman M. Double-blind controlled trial of immunosuppression in the treatment of multiple sclerosis: final report. Lancet. 1982 Aug 14;2(8294):351–354. doi: 10.1016/s0140-6736(82)90547-5. [DOI] [PubMed] [Google Scholar]
  20. Mitchell D. N., Porterfield J. S., Micheletti R., Lange L. S., Goswami K. K., Taylor P., Jacobs J. P., Hockley D. J., Salsbury A. J. Isolation of an infectious agent from bone-marrows of patients with multiple sclerosis. Lancet. 1978 Aug 19;2(8086):387–391. doi: 10.1016/s0140-6736(78)91862-7. [DOI] [PubMed] [Google Scholar]
  21. Paty D. W., Cousin H. K., Read S., Adlakha K. Linoleic acid in multiple sclerosis: failure to show any therapeutic benefit. Acta Neurol Scand. 1978 Jul;58(1):53–58. doi: 10.1111/j.1600-0404.1978.tb02859.x. [DOI] [PubMed] [Google Scholar]
  22. Prasad I., Broome J. D., Pertschuk L. P., Gupta J., Cook A. W. Recovery of Paramyxovirus from the jejunum of patients with multiple sclerosis. Lancet. 1977 May 28;1(8022):1117–1119. doi: 10.1016/s0140-6736(77)92381-9. [DOI] [PubMed] [Google Scholar]
  23. Schapira M. Treating multiple sclerosis with amantadine hydrochloride. J R Coll Gen Pract. 1974 Jun;24(143):411–412. [PMC free article] [PubMed] [Google Scholar]
  24. Segal A. W. Variations on the theme of chronic granulomatous disease. Lancet. 1985 Jun 15;1(8442):1378–1383. doi: 10.1016/s0140-6736(85)91796-9. [DOI] [PubMed] [Google Scholar]
  25. Shepherd D. I., Downie A. W. A further prevalence study of multiple sclerosis in north-east Scotland. J Neurol Neurosurg Psychiatry. 1980 Apr;43(4):310–315. doi: 10.1136/jnnp.43.4.310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Sibley W. A., Bamford C. R., Clark K. Clinical viral infections and multiple sclerosis. Lancet. 1985 Jun 8;1(8441):1313–1315. doi: 10.1016/S0140-6736(85)92801-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Stephenson J. R., ter Meulen V., Kiessling W. Search for canine-distemper-virus antibodies in multiple sclerosis. A detailed virological evaluation. Lancet. 1980 Oct 11;2(8198):772–775. doi: 10.1016/s0140-6736(80)90387-6. [DOI] [PubMed] [Google Scholar]
  28. Sumaya C. V., Myers L. W., Ellison G. W. Epstein-Barr virus antibodies in multiple sclerosis. Arch Neurol. 1980 Feb;37(2):94–96. doi: 10.1001/archneur.1980.00500510052009. [DOI] [PubMed] [Google Scholar]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

RESOURCES