Figure 7.
Bone phenotype in ARKO mice. (A) Hematoxylin and eosin-stained femoral bones of 8-week-old wt and ARKO mice. Note the decreased trabecular bone area in the distal metaphysis of the ARKO mouse compared with wt littermates. (B) Calcein double labeling in 8-week-old wt and ARKO mice. The mean distance between the two yellow labels (white lines) represents the rate of bone mineralization from which the rate of bone formation is calculated. (C) Bone volume and osteoclast numbers data in ARKO and wt mice. Data are from six ARKO male mice and the same number of male and female littermates. (D) Mineral apposition and bone formation rate data in ARKO and wt mice. Data are from three ARKO mice and the same number of wt littermates. *, statistically significant differences compared with control mice (P < 0.05). Error bars represent SD.