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. 2005 Dec 6;102(50):18123–18128. doi: 10.1073/pnas.0509145102

Table 1. Cardiac morphology, fibrosis, and disarray in WT and MHC403/+ mice.

MHC403/+ arrhythmia
WT MHC403/+ P* Inducible Not Inducible P**
No. of mice 5 16 11 5
Age, weeks 71 ± 23 57 ± 21 NS 56 ± 15 59 ± 32 NS
Total fibrosis 0.17 ± 0.24 0.98 ± 0.75 0.001 1.10 ± 0.86 0.72 ± 0.39 NS
Max fibrosis 0.66 ± 0.68 2.58 ± 1.85 0.002 2.85 ± 2.0 1.99 ± 1.6 NS
Myocyte disarray 8.07 ± 4.28 40.07 ± 11.02 <0.0001 38.89 ± 10 41.01 ± 13 NS
Maximum LVWT, mm 0.85 ± 0.05 1.17 ± 0.13 <0.001 1.29 ± 0.09 1.1 ± 0.09 0.008
LVEDD, mm 3.29 ± 0.3 2.70 ± 0.33 0.002 2.37 ± 0.29 2.87 ± 0.20 0.005
FS, % 51.6 ± 6.7 64.25 ± 10.88 0.005 73.8 ± 11 59.5 ± 8 0.024
CV min, m/s 0.43 ± 0.10 0.41 ± 0.10 NS 0.34 ± 0.13 0.46 ± 0.11 NS
CV max, m/s 0.69 ± 0.14 0.76 ± 0.13 NS 0.75 ± 0.10 0.85 ± 0.13 NS
Anisotropic ratio 1.63 ± 0.22 1.99 ± 0.56 NS 2.37 ± 0.61 1.98 ± 0.68 NS

Values reflect means ± standard deviation. P*, t test comparison of WT vs. MHC403/+ mice; P**, t test comparison of MHC403/+ mice with inducible arrhythmias versus MHC403/+ mice without inducible arrhythmias; NS, not significant; Max fibrosis, maximum fibrosis on any heart section; Myocyte disarray, total disarrayed area/total LV area; LVEDD, left ventricular end diastolic diameter; FS, fractional shortening; CV min, minimal signal conduction velocity; CV max, maximal signal conduction velocity.