TABLE 1.
Survival of mice after intranasal challenge with B. anthracis spores
| Group no. | Immunization method | rPA (μg) | Adjuvant (μg) | % Survival on day 14 (no. of survivors/ no. challenged) (Pb) | MTDc |
|---|---|---|---|---|---|
| 1 | TCI | 20a | HLT (4) | 50 (5/10) (0.007) | 3.5 |
| 2 | TCI | 20 | HLT (4) | 60 (6/10) (0.010) | 3.0 |
| 3 | TCI | 5 | HLT (4) | 20 (2/10) (0.281) | 2.9 |
| 4 | TCI | 1 | HLT (4) | 30 (3/10) (0.055) | 3.3 |
| 5 | TCI | 0.2 | HLT (4) | 60 (6/10) (0.010) | 3.0 |
| 6 | i.m. | 20a | Alum | 10 (1/10) | 2.8 |
| Nonimmunized | None | None | None | 10 (1/10) | 4.4 |
a
rPA was purchased from List Biological Laboratories.
b
Significance value represents a comparison of group 6 i.m. immunized mice versus TCI mice.
c
MTD, mean time to death of animals that died, in days.