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Inhibition of urate oxidase with potassium oxonate delays UA metabolism in mice. Groups of mice (n = 3–4) were immunized with MBP as detailed in Experimental Procedures and injected i.p with UA (1, 5, or 10 mg) and K-Ox (1, 5, or 10 mg) as indicated. Serum samples were collected 30 min, 1 h, 4 h, and 8 h postinjection. Serum UA levels were assessed by HPLC as described in Experimental Procedures. Data are presented as mean ± SD.
