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. 2006 Mar 7;103(11):4134–4139. doi: 10.1073/pnas.0511342103

Fig. 4.

Fig. 4.

TSC2 mediates the effects of Akt1 on motility and invasion. (A) TSC2 shows increased phosphorylation but decreased total levels in cells expressing myr-Akt1. (B) Decreased levels of TSC2 in tumor xenografts from myr-Akt1 cells. (Scale bar: 50 μm.) (C) TSC2 shows increased association with 14-3-3 in cells expressing myr-Akt1. (D) Expression of functional TSC2 in myr-Akt1 cells as shown by reduced phosphorylation of p70S6K. (E) Expression of TSC2 rescues cell invasiveness and motility in myr-Akt1 cells. The graphs display averages ± SEM. ∗, P < 0.05; ∗∗, P < 0.02; ∗∗∗, P < 0.001.