Skip to main content
Annals of Surgery logoLink to Annals of Surgery
. 1977 Apr;185(4):456–461. doi: 10.1097/00000658-197704000-00015

A clinicopathologic study of sex cases.

J M Davis, G F Gray, B Thorbjarnarson
PMCID: PMC1396142  PMID: 843140

Abstract

Six patients with surgically treated Menetrier's disease are presented. Diffuse or focal cystic hyperplasia of mucous secreting epithelium of the fundus with antral sparing characterized the stomachs in all of these cases. In most instances the disorder was found during evaluation of non-specific complaints of pain, nausea and diarrhea. Only one patient had sufficient loss of albumin to produce server ankle edema and four of the others had below normal serum albumin levels without associated symptoms. One patient presented with life threatening bleeding from the hyperplastic mucosa. None of the patients had an associated endocrine neoplasm. All of the patients are living and without symptoms of disease for periods ranging from three to twelve years after resection of all or part of the hyperplastic mucosa. The rationale for surgical therapy in this condition is presented.

Full text

PDF
456

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albo R. J., Peters H. E., Williams R. R. Giant hypertrophic gastritis. Am J Surg. 1973 Aug;126(2):229–234. doi: 10.1016/s0002-9610(73)80157-6. [DOI] [PubMed] [Google Scholar]
  2. Brooks A. M., Isenberg J., Goldstein H. Giant thickening of the gastric mucosa with acid hypersecretion and protein-losing gastropathy. Gastroenterology. 1970 Jan;58(1):73–79. [PubMed] [Google Scholar]
  3. Brown H. W., Riahi M. Menetrier's disease or giant hypertrophic gastritis. A report of four cases with review of the literature. Int Surg. 1966 Apr;45(4):403–413. [PubMed] [Google Scholar]
  4. CHUSID E. L., HIRSCH R. L., COLCHER H. SPECTRUM OF HYPERTROPHIC GASTROPATHY; GIANT RUGAL FOLDS, POLYPOSIS, AND CARCINOMA OF THE STOMACH--CASE REPORT AND REVIEW OF THE LITERATURE. Arch Intern Med. 1964 Nov;114:621–628. doi: 10.1001/archinte.1964.03860110091008. [DOI] [PubMed] [Google Scholar]
  5. CITRIN Y., STERLING K., HALSTED J. A. The mechanism of hypoproteinemia associated with giant hypertrophy of the gastric mucosa. N Engl J Med. 1957 Nov 7;257(19):906–912. doi: 10.1056/NEJM195711072571902. [DOI] [PubMed] [Google Scholar]
  6. HOLMAN H., NICKEL W. F., Jr, SLEISENGER M. H. Hypoproteinemia antedating intestinal lesions, and possibly due to excessive serum protein loss into the intestine. Am J Med. 1959 Dec;27:963–975. doi: 10.1016/0002-9343(59)90180-9. [DOI] [PubMed] [Google Scholar]
  7. KENNEY F. D., DOCKERTY M. B., WAUGH J. M. Giant hypertrophy of gastric mucosa; a clinical and pathological study. Cancer. 1954 Jul;7(4):671–681. doi: 10.1002/1097-0142(195407)7:4<671::aid-cncr2820070407>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  8. MATZNER M. J., RAAB A. P., SPEAR P. W. Benign giant gastric rugae complicated by submucosal gastric carcinoma; report of case. Gastroenterology. 1951 Jun;18(2):296–302. [PubMed] [Google Scholar]
  9. PITTMAN F. E., HARRIS R. C., BARKER H. G. TRANSIENT EDEMA AND HYPOPROTEINEMIA. POSSIBLE MENETRIER'S DISEASE. Am J Dis Child. 1964 Aug;108:189–197. doi: 10.1001/archpedi.1964.02090010191013. [DOI] [PubMed] [Google Scholar]
  10. Palmer E. D. What Menetrier really said. Gastrointest Endosc. 1968 Nov;15(2):83–passim. [PubMed] [Google Scholar]
  11. Pearse A. G. The APUD cell concept and its implications in pathology. Pathol Annu. 1974;9(0):27–41. [PubMed] [Google Scholar]
  12. REESE D. F., HODGSON J. R., DOCKERTY M. B. Giant hypertrophy of the gastric mucosa (Menetrier's disease):a correlation of the roentgenographic, pathologic, and clinical findings. Am J Roentgenol Radium Ther Nucl Med. 1962 Oct;88:619–626. [PubMed] [Google Scholar]
  13. ROXBURGH R. A. The case for total gastrectomy in multiple polyposis of the stomach. Gut. 1962 Sep;3:224–231. doi: 10.1136/gut.3.3.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. STEMPIEN S. J., DAGRADI A. E., REINGOLD I. M., HEISKELL C. L., GOODMAN J. R., BLOOM A., WEAVER D. S. HYPERTROPHIC HYPERSECRETORY GASTROPATHY. ANALYSIS OF 15 CASES AND A REVIEW OF THE PERTINENT LITERATURE. Am J Dig Dis. 1964 Jul;9:471–493. doi: 10.1007/BF02283918. [DOI] [PubMed] [Google Scholar]
  15. Scott H. W., Jr, Shull H. J., Law D. H., 4th, Burko H., Page D. L. Surgical management of Menetrier's disease with protein-losing gastropathy. Ann Surg. 1975 May;181(5):765–777. doi: 10.1097/00000658-197505000-00036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Singh A. K., Cumaraswamy R. C., Corrin B. Diffuse hypertrophy of gastric mucosa (Menétrier's disease) and iron-deficiency anaemia. Gut. 1969 Sep;10(9):735–737. doi: 10.1136/gut.10.9.735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. TEXTER E. C., Jr, LEGERTON C. W., Jr, REEVES R. J., SMITH A. G., RUFFIN J. M. Coexistent carcinoma of the stomach and hypertrophic gastritis; report of a case with review of the literature. Gastroenterology. 1953 Aug;24(4):579–586. [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES