TABLE 1.
Nipped-A mutations in Tra1/TRRAP
| Allele | Mutation(s)a | Type | Encoded proteinb | Reference |
|---|---|---|---|---|
| NC96 | T73046C | 3′ UTR | 1-3790 (wild-type) | This work |
| NC105 | A62691T | Splice acceptor | 1-2048 + 5 | This work |
| NC106 | T33610A, G33613C | Splice acceptor | 1-263 + 2 | This work |
| NC186 | T52327A | V1191D | 1-3790 (missense) | 38 |
| NC194 | A54590T | K1501STOP | 1-1500 | This work |
a
The numbering is based on a hybrid sequence with the first nucleotide of the most 5′ RACE product from cn bw defined as nucleotide 1. The hybrid sequence was generated by substituting the cn bw exon sequences determined here into the wild-type genomic sequence generated by the Drosophila genome project (8). There are multiple polymorphic differences in both exon and intron sequences between the cn bw and Drosophila genome sequences, but the hybrid sequence is used because we did not fully sequence all cn bw introns.
b
The numbers refer to the residues encoded by the major Nipped-A/Tra1/TRRAP transcript determined in this work.