FIG. 2.
Colonization and prophylactic immunization of wt and knockout mice of the C57BL/6J background with H. pylori SS1S. (A) The rates of colonization of C57BL/6J wt, IL-10−/−, p55−/−, and p55/75−/− mice are shown. The medians for groups are given as percentages of H. pylori recovery. (B) Data for single mice are given as CFU per gram of stomach. The experiment lasted for 31 weeks (see Materials and Methods). Bars: 1, wt, infected; 2, wt, immunized and infected; 3, IL-10−/−, infected; 4, IL-10−/−, immunized and infected; 5, p55−/−, infected; 6, p55−/−, immunized and infected; 7, p55/p75−/−, infected; 8, p55/p75−/−, immunized and infected. When the colonization rates of infected mice were compared to those of the corresponding immunized and infected mice, all groups differed significantly (P < 0.05), with the exception of the IL-10−/− mice (panel B, bars 3 and 4) (P = 0.715). Rates of colonization of infected wt mice differed significantly from those of the knockout groups (P < 0.05), with the following exceptions: p55−/− infected only (panel B, bars 1 and 5) (P = 0.5002), p55/75−/− infected only (panel B, bars 1 and 7) (P = 0.0796), and p55/75−/− immunized and infected (panel B, bars 2 and 8) (P = 0.5002). The groups presented in Fig. 1 and 2 were evaluated in the same experiment, and the wt control experiments were therefore with the same animals. *, P < 0.05