Table 2.
HI serology and survival of chickens before and after challenge
| Vaccine group* | HI serology before challenge (GMT) |
Challenge virus | No. of survivors | HI serology 14 days after challenge (GMT) |
||
|---|---|---|---|---|---|---|
| AIV/H7 antigen | NDV antigen | AIV/H7 antigen | NDV antigen | |||
| rNDV/F3aa-chimericH7, 1× | 8/10 (11) | 10/10 (49) | vNDV | 10/10 | 9/10 (15) | 10/10 (416) |
| rNDV/F3aa-chimericH7, 1× | 7/10 (10) | 10/10 (49) | HPAIV | 9/10 | 9/9 (2,048) | 9/9 (37) |
| rNDV/F3aa-chimericH7, 2× | 8/10 (13) | 9/10 (56) | vNDV | 10/10 | 7/10 (17) | 10/10 (315) |
| rNDV/F3aa-chimericH7, 2× | 5/10 (9) | 9/10 (60) | HPAIV | 9/10 | 8/8 (955) | 8/8 (30) |
| pNDV, 2× | 0/10 | 10/10 (34) | vNDV | 10/10 | 0/10 | 10/10 (294) |
| pNDV, 2× | 0/10 | 10/10 (56) | HPAIV | 0/10 | NA | NA |
| Sham, 2× | 0/10 | 0/10 | vNDV | 0/10 | NA | NA |
| Sham, 2× | 0/10 | 0/10 | HPAIV | 3/10 | 0/3 | 0/3 |
Chickens were vaccinated with rNDV containing the AIV H7 HA gene (rNDV/F3aa-chimericH7), pNDV, or sterile tissue culture fluid (sham), followed by challenge with vNDV and A/Human/Steele/59 (H7N7) HPAI virus (HPAIV). HI serology is shown as no. of chickens with HI-positive serum/no. of chickens vaccinated; values in parentheses are geometric mean titer (GMT). NA, not applicable.
*n = 10 birds per group; 1× = one vaccination; 2× = two vaccinations.