Table 7.
Effect of chemoreceptor deafferentations on the thermogenic, metabolic and cardiovascular responses to systemic administration of NaCN and to ventilation with 8% O2
| Control | Bic RPa | NaCN | 8% O2 | |
|---|---|---|---|---|
| BAT SNA (% control) | 100 | 923 ± 193* | 1102 ± 339* | 819 ± 14* |
| BAT temp. (°C) | 34.7 ± 0.6 | 35.4 ± 0.5* | 35.3 ± 0.6* | 35.4 ± 0.5* |
| Expired CO2 (%) | 5.1 ± 0.3 | 5.7 ± 0.2* | 5.7 ± 0.2* | 5.6 ± 0.1* |
| HR (beats min−1) | 434 ± 13 | 476 ± 14* | 476 ± 13* | 455 ± 35 |
| MAP (mmHg) | 114 ± 6 | 125 ± 6 | 106 ± 3 | 82 ± 1*† |
Physiological variables in rats in which the carotid sinus nerves have been transected bilaterally. Values are means ± s.e.m. (n = 3) in the control condition, at the peak response within 10 min of the microinjection of bicuculline (Bic) into the RPa, at the minimum level within five minutes of subsequent intravenous injection of NaCN, and at the minimum level during ventilation with 8% O2.
*
P < 0.05 compared to the control condition.
†
P < 0.05 compared to the Bic RPa condition.