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. 1997 Mar;105(Suppl 2):521–526. doi: 10.1289/ehp.97105s2521

Pavlovian conditioning and multiple chemical sensitivity.

S Siegel 1, R Kreutzer 1
PMCID: PMC1469825  PMID: 9167990

Abstract

Pavlovian conditioning processes may contribute to some symptoms of multiple chemical sensitivity (MCS). This review summarizes the potential relevance of the literature on conditional taste and olfactory aversions, conditional sensitization, and conditional immunomodulation to understanding MCS. A conditioning-based perspective on MCS suggests novel research and treatment strategies.

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Selected References

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  1. Ader R., Cohen N. Behaviorally conditioned immunosuppression and murine systemic lupus erythematosus. Science. 1982 Mar 19;215(4539):1534–1536. doi: 10.1126/science.7063864. [DOI] [PubMed] [Google Scholar]
  2. Ader R., Felten D., Cohen N. Interactions between the brain and the immune system. Annu Rev Pharmacol Toxicol. 1990;30:561–602. doi: 10.1146/annurev.pa.30.040190.003021. [DOI] [PubMed] [Google Scholar]
  3. Alarie Y. Irritating properties of airborne materials to the upper respiratory tract. Arch Environ Health. 1966 Oct;13(4):433–449. doi: 10.1080/00039896.1966.10664593. [DOI] [PubMed] [Google Scholar]
  4. Alleva E., Calamandrei G. Odor-aversion learning and retention span in neonatal mouse pups. Behav Neural Biol. 1986 Nov;46(3):348–357. doi: 10.1016/s0163-1047(86)90317-1. [DOI] [PubMed] [Google Scholar]
  5. Andrykowski M. A., Otis M. L. Development of learned food aversions in humans: investigation in a "natural laboratory" of cancer chemotherapy. Appetite. 1990 Apr;14(2):145–158. doi: 10.1016/0195-6663(90)90016-2. [DOI] [PubMed] [Google Scholar]
  6. Arwas S., Rolnick A., Lubow R. E. Conditioned taste aversion in humans using motion-induced sickness as the US. Behav Res Ther. 1989;27(3):295–301. doi: 10.1016/0005-7967(89)90049-1. [DOI] [PubMed] [Google Scholar]
  7. Bell I. R., Peterson J. M., Schwartz G. E. Medical histories and psychological profiles of middle-aged women with and without self-reported illness from environmental chemicals. J Clin Psychiatry. 1995 Apr;56(4):151–160. [PubMed] [Google Scholar]
  8. Bolla-Wilson K., Wilson R. J., Bleecker M. L. Conditioning of physical symptoms after neurotoxic exposure. J Occup Med. 1988 Sep;30(9):684–686. [PubMed] [Google Scholar]
  9. Chang J. C., Steinhagen W. H., Barrow C. S. Effect of single or repeated formaldehyde exposure on minute volume of B6C3F1 mice and F-344 rats. Toxicol Appl Pharmacol. 1981 Dec;61(3):451–459. doi: 10.1016/0041-008x(81)90368-9. [DOI] [PubMed] [Google Scholar]
  10. Clinical ecology. American College of Physicians. Ann Intern Med. 1989 Jul 15;111(2):168–178. [PubMed] [Google Scholar]
  11. Darling F. M., Slotnick B. M. Odor-cued taste avoidance: a simple and efficient method for assessing olfactory detection, discrimination and memory in the rat. Physiol Behav. 1994 May;55(5):817–822. doi: 10.1016/0031-9384(94)90065-5. [DOI] [PubMed] [Google Scholar]
  12. Doty R. L. Olfaction and multiple chemical sensitivity. Toxicol Ind Health. 1994 Jul-Oct;10(4-5):359–368. [PubMed] [Google Scholar]
  13. Guglielmi R. S., Cox D. J., Spyker D. A. Behavioral treatment of phobic avoidance in multiple chemical sensitivity. J Behav Ther Exp Psychiatry. 1994 Sep;25(3):197–209. doi: 10.1016/0005-7916(94)90020-5. [DOI] [PubMed] [Google Scholar]
  14. Jacobsen P. B., Bovbjerg D. H., Schwartz M. D., Andrykowski M. A., Futterman A. D., Gilewski T., Norton L., Redd W. H. Formation of food aversions in cancer patients receiving repeated infusions of chemotherapy. Behav Res Ther. 1993 Nov;31(8):739–748. doi: 10.1016/0005-7967(93)90004-e. [DOI] [PubMed] [Google Scholar]
  15. Justesen D. R., Braun E. W., Garrison R. G., Pendleton R. B. Pharmacological differentiation of allergic and classically conditioned asthma in the guinea pig. Science. 1970 Nov 20;170(3960):864–866. doi: 10.1126/science.170.3960.864. [DOI] [PubMed] [Google Scholar]
  16. Kane L. E., Alarie Y. Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice. Am Ind Hyg Assoc J. 1977 Oct;38(10):509–522. doi: 10.1080/0002889778507665. [DOI] [PubMed] [Google Scholar]
  17. Kinney N. E., Wright J. W., Harding J. W. Motion-induced aversions during and after recovery from olfactory nerve section in mice. Physiol Behav. 1993 Apr;53(4):631–633. doi: 10.1016/0031-9384(93)90166-d. [DOI] [PubMed] [Google Scholar]
  18. MacQueen G., Marshall J., Perdue M., Siegel S., Bienenstock J. Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II. Science. 1989 Jan 6;243(4887):83–85. doi: 10.1126/science.2911721. [DOI] [PubMed] [Google Scholar]
  19. McGovern J. J., Jr, Lazaroni J. A., Hicks M. F., Adler J. C., Cleary P. Food and chemical sensitivity. Clinical and immunologic correlates. Arch Otolaryngol. 1983 May;109(5):292–297. doi: 10.1001/archotol.1983.00800190014004. [DOI] [PubMed] [Google Scholar]
  20. Melchior C. L. Conditioned tolerance provides protection against ethanol lethality. Pharmacol Biochem Behav. 1990 Sep;37(1):205–206. doi: 10.1016/0091-3057(90)90063-n. [DOI] [PubMed] [Google Scholar]
  21. Neutra R. R. Some preliminary thoughts on the potential contribution of epidemiology to the question of multiple chemical sensitivity. Public Health Rev. 1994;22(3-4):271–278. [PubMed] [Google Scholar]
  22. Nielsen G. D. Mechanisms of activation of the sensory irritant receptor by airborne chemicals. Crit Rev Toxicol. 1991;21(3):183–208. doi: 10.3109/10408449109089879. [DOI] [PubMed] [Google Scholar]
  23. OTTENBERG P., STEIN M., LEWIS J., HAMILTON C. Learned asthma in the guinea pig. Psychosom Med. 1958 Sep-Oct;20(5):395–400. doi: 10.1097/00006842-195809000-00007. [DOI] [PubMed] [Google Scholar]
  24. Parker L. A., Hutchison S., Riley A. L. Conditioned flavor aversions: a toxicity test of the anticholinesterase agent, physostigmine. Neurobehav Toxicol Teratol. 1982 Jan-Feb;4(1):93–98. [PubMed] [Google Scholar]
  25. Peeke H. V., Dark K., Ellman G., McCurry C., Salfi M. Prior stress and behaviorally conditioned histamine release. Physiol Behav. 1987;39(1):89–93. doi: 10.1016/0031-9384(87)90349-0. [DOI] [PubMed] [Google Scholar]
  26. Pennebaker J. W. Psychological bases of symptom reporting: perceptual and emotional aspects of chemical sensitivity. Toxicol Ind Health. 1994 Jul-Oct;10(4-5):497–511. [PubMed] [Google Scholar]
  27. Riccio D. C., Ackil J., Burch-Vernon A. Forgetting of stimulus attributes: methodological implications for assessing associative phenomena. Psychol Bull. 1992 Nov;112(3):433–445. doi: 10.1037/0033-2909.112.3.433. [DOI] [PubMed] [Google Scholar]
  28. Riley A. L., Tuck D. L. Conditioned taste aversions: a behavioral index of toxicity. Ann N Y Acad Sci. 1985;443:272–292. doi: 10.1111/j.1749-6632.1985.tb27079.x. [DOI] [PubMed] [Google Scholar]
  29. Siegel S., Hinson R. E., Krank M. D., McCully J. Heroin "overdose" death: contribution of drug-associated environmental cues. Science. 1982 Apr 23;216(4544):436–437. doi: 10.1126/science.7200260. [DOI] [PubMed] [Google Scholar]
  30. Spector A. C., Breslin P., Grill H. J. Taste reactivity as a dependent measure of the rapid formation of conditioned taste aversion: a tool for the neural analysis of taste-visceral associations. Behav Neurosci. 1988 Dec;102(6):942–952. doi: 10.1037//0735-7044.102.6.942. [DOI] [PubMed] [Google Scholar]
  31. Spyker D. A. Multiple chemical sensitivities--syndrome and solution. J Toxicol Clin Toxicol. 1995;33(2):95–99. doi: 10.3109/15563659509000456. [DOI] [PubMed] [Google Scholar]
  32. Terr A. I. Environmental illness. A clinical review of 50 cases. Arch Intern Med. 1986 Jan;146(1):145–149. doi: 10.1001/archinte.146.1.145. [DOI] [PubMed] [Google Scholar]
  33. Turenne S. D., Miles C., Parker L. A., Siegel S. Individual differences in reactivity to the rewarding/aversive properties of drugs: assessment by taste and place conditioning. Pharmacol Biochem Behav. 1996 Mar;53(3):511–516. doi: 10.1016/0091-3057(95)02042-x. [DOI] [PubMed] [Google Scholar]
  34. Vila J. Protection from pentobarbital lethality mediated by Pavlovian conditioning. Pharmacol Biochem Behav. 1989 Jan;32(1):365–366. doi: 10.1016/0091-3057(89)90257-8. [DOI] [PubMed] [Google Scholar]
  35. Wood R. W., Coleman J. B. Behavioral evaluation of the irritant properties of formaldehyde. Toxicol Appl Pharmacol. 1995 Jan;130(1):67–72. doi: 10.1006/taap.1995.1009. [DOI] [PubMed] [Google Scholar]
  36. Ziem G. Physical symptoms after neurotoxic exposure. J Occup Med. 1989 Apr;31(4):410–411. [PubMed] [Google Scholar]

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