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. Author manuscript; available in PMC: 2006 May 31.
Published in final edited form as: Circ Res. 2005 Dec 22;98(2):254–261. doi: 10.1161/01.RES.0000200740.57764.52

Figure 5.

Figure 5.

Increased apoptosis in GPx-1 KO EPCs in response to oxidative stress. A, Quantitative analysis of TUNEL staining in cultured EPCs. EPCs from GPx-1 KO and WT mice were incubated 12 hours in the presence or absence of 500 μmol/L H2O2. Data are shown as mean±SD. **P<0.001 vs WT plus H2O2, vs KO without H2O2; n=5. B, Quantitative analysis of Annexin V staining. After ischemic surgery, EPCs were isolated and cultured in the presence or absence of H2O2. Annexin V staining was detected by FACS analysis. Data are reported as mean±SD. KO EPCs after addition of H2O2 are significantly more sensitive to apoptosis compared with WT EPCs (**P<0.001 vs WT plus H2O2, n=5).