Table 1.
Gene functional categories with three or more GAF targets
| Gene Ontology category | GAF target genes in category |
|---|---|
| Biological processes | |
| Amino acid metabolism | SelD, Gad1, slgA |
| Catabolism | Gad1, eff, slgA |
| Cell communication | PGRP-LA, Dad, grk |
| Cell growth and/or maintenance | Fer1HCH, Cdk4, stg, PGRP-LA, LamC, SelD, Gad1, eff, ash2, Alhambra, slgA, chic |
| Defense response | PGRP-LA, CG3829, spz, Myd88 |
| Developmental processes | mfas, grk, fray |
| Heat shock response | Hsp22, Hsp26, Hsp27 |
| Imaginal disc growth factor | Idgf2, Idgf3, Idgf1 |
| Ligand binding or carrier | Fer1HCH, Nrv2, CG6783, Ras85D, dome, Cyt-c-d, chic |
| Mitosis | LamC, eff, eIF-4E, stg |
| Protein amino acid dephosphorylation | CG11597, stg, PP2A–B′, dome, puc |
| Protein amino acid phosphorylation | Cdk4, par-1, for, par-1, Pak3, gish, fray, CG10967, for, Lk6 |
| Signal transduction | Dad, grk, Myd88 |
| Molecular functions | |
| Actin binding | cpb, bif, chic |
| DNA binding | Eli, Tis11, E2f, D1, HmgD, Alhambra, Rbf |
| Establishment/maintenance of chromatin architecture | HmgD, ash2, eIF-4E |
| Glutathione transferase | CG17531, CG17533, CG5224, CG1681 |
| Heat shock protein | Hsp22, Hsp26, Hsp27 |
| Hydrolase | Nrv2, CG11597, Idgf3, Faa, PP2A–B′, CG8689, Ras85D, aay, puc, CG9026, ESTS:172F5T, CG10992 |
| Hydrolase, acting on glycosyl bonds | Idgf3, CG8689, ESTS:172F5T |
| Integral plasma membrane protein | Nrv2, PGRP-LA, CG3829 |
| Ion transporter | Nrv2, BcDNA:LD28120, Sip1 |
| Kinase | SelD, CG1216, CG4798 |
| Ligand | Idgf3, grk, spz |
| Oxidoreductase | Gs1, BEST:CK02318, Mdh, CG6199, slgA, CG15093, Sptr |
| Oxidoreductase CH-OH group of donors | Mdh, CG15093, Sptr |
| Phosphatase | CG11597, PP2A–B′, aay, puc, stg, dome |
| Protein serine/threonine kinase | Cdk4, for, par-1, fray, CG10967, for, Lk6 |
| Serpin | sp1, Spn43Aa, sp4 |
| Signal transducer | Idgf3, dome, grk, spz |
| Transcription factor | E2f, E11, CG11799, CG11867, Iola, NK7.1 |
| Transferase | CG1140, Ugt35a, CG8782, SelD, CG5431, CG1681, CG1216, CG4798, Ugt35b |
| Translation initiation factor | eIF-4a, eIF-4E, Syx1A |
| Transporter | Nrv2, BcDNA:LD28120, Sip1 |
| UDP-glucuronosyltransferase | Ugt35a, Ugt86Da, Ugt35b |
Standardized gene annotations were taken from the Drosophila Gene Ontology database (release February 2002). A complete list of target genes can be found in Table 4.