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. 1986 Nov;66(2):457–462.

Development of anti-polysaccharide antibodies in asplenic children.

L Hammarström, C I Smith
PMCID: PMC1542520  PMID: 3815900

Abstract

Splenectomized patients are highly susceptible to infections with capsulated bacteria and an impaired response to vaccination with bacterial polysaccharides has frequently been observed in these individuals. Based partly on experimental animal data, an important role for the spleen in the production of specific anti-carbohydrate antibodies, i.e. mostly IgG2 in normal adults, has been suggested. We therefore determined the immunoglobulin class and subclass pattern of serum antibodies from asplenic patients against protein and carbohydrate antigens. Normal levels of total serum IgM, IgG2 and specific IgM and IgG2 anti-polysaccharide antibodies were observed, suggesting only a minor role for the spleen in determining the antibody repertoire. The data imply that the impaired phagocytic capacity and/or the inability to mount a sufficiently rapid antibody response are the main factors underlying the increased susceptibility to bacterial infections noted in these patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amlot P. L., Hayes A. E. Impaired human antibody response to the thymus-independent antigen, DNP-Ficoll, after splenectomy. Implications for post-splenectomy infections. Lancet. 1985 May 4;1(8436):1008–1011. doi: 10.1016/s0140-6736(85)91613-7. [DOI] [PubMed] [Google Scholar]
  2. Ammann A. J., Addiego J., Wara D. W., Lubin B., Smith W. B., Mentzer W. C. Polyvalent pneumococcal-polysaccharide immunization of patients with sickle-cell anemia and patients with splenectomy. N Engl J Med. 1977 Oct 27;297(17):897–900. doi: 10.1056/NEJM197710272971701. [DOI] [PubMed] [Google Scholar]
  3. Briles D. E., Nahm M., Schroer K., Davie J., Baker P., Kearney J., Barletta R. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae. J Exp Med. 1981 Mar 1;153(3):694–705. doi: 10.1084/jem.153.3.694. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Freijd A., Hammarström L., Persson M. A., Smith C. I. Plasma anti-pneumococcal antibody activity of the IgG class and subclasses in otitis prone children. Clin Exp Immunol. 1984 May;56(2):233–238. [PMC free article] [PubMed] [Google Scholar]
  5. Gray D., Kumararatne D. S., Lortan J., Khan M., MacLennan I. C. Relation of intra-splenic migration of marginal zone B cells to antigen localization on follicular dendritic cells. Immunology. 1984 Aug;52(4):659–669. [PMC free article] [PubMed] [Google Scholar]
  6. Gray D., McConnell I., Kumararatne D. S., MacLennan I. C., Humphrey J. H., Bazin H. Marginal zone B cells express CR1 and CR2 receptors. Eur J Immunol. 1984 Jan;14(1):47–52. doi: 10.1002/eji.1830140109. [DOI] [PubMed] [Google Scholar]
  7. Hammarström L., Granström M., Möllby R., Oxelius V., Persson M. A., Smith C. I. Ontogeny of IgG2 antibodies against S. aureus teichoic acid in normal and immunodeficient children. Acta Paediatr Scand. 1985 Jan;74(1):126–130. doi: 10.1111/j.1651-2227.1985.tb10933.x. [DOI] [PubMed] [Google Scholar]
  8. Hammarström L., Persson M. A., Smith C. I. Immunoglobulin subclass distribution of human anti-carbohydrate antibodies: aberrant pattern in IgA-deficient donors. Immunology. 1985 Apr;54(4):821–826. [PMC free article] [PubMed] [Google Scholar]
  9. Hosea S. W., Burch C. G., Brown E. J., Berg R. A., Frank M. M. Impaired immune response of splenectomised patients to polyvalent pneumococcal vaccine. Lancet. 1981 Apr 11;1(8224):804–807. doi: 10.1016/s0140-6736(81)92681-7. [DOI] [PubMed] [Google Scholar]
  10. Johansen K. S., Pedersen F. K. Antibody response and opsonization afer pneumococcal vaccination in splenectomized children and healthy persons. Acta Pathol Microbiol Immunol Scand C. 1982 Oct;90(5):265–270. doi: 10.1111/j.1699-0463.1982.tb01448.x. [DOI] [PubMed] [Google Scholar]
  11. Minor D. R., Schiffman G., McIntosh L. S. Response of patients with Hodgkin's disease to pneumococcal vaccine. Ann Intern Med. 1979 Jun;90(6):887–892. doi: 10.7326/0003-4819-90-6-887. [DOI] [PubMed] [Google Scholar]
  12. Morell A., Skvaril F., Hijmans W., Scherz R. Cytoplasmic immunofluorescence of bone marrow plasma cells producing immunoglobulins of the four IgG subclasses. J Immunol. 1975 Aug;115(2):579–583. [PubMed] [Google Scholar]
  13. Oldfield S., Jenkins S., Yeoman H., Gray D., MacLennan I. C. Class and subclass anti-pneumococcal antibody responses in splenectomized patients. Clin Exp Immunol. 1985 Sep;61(3):664–673. [PMC free article] [PubMed] [Google Scholar]
  14. Oxelius V. A. IgG subclass levels in infancy and childhood. Acta Paediatr Scand. 1979 Jan;68(1):23–27. doi: 10.1111/j.1651-2227.1979.tb04424.x. [DOI] [PubMed] [Google Scholar]
  15. Pedersen F. K., Henrichsen J., Schiffman G. Antibody response to vaccination with pneumococcal capsular polysaccharides in splenectomized children. Acta Paediatr Scand. 1982 May;71(3):451–455. doi: 10.1111/j.1651-2227.1982.tb09451.x. [DOI] [PubMed] [Google Scholar]
  16. Pedersen F. K., Nielsen J. L., Ellegaard J. Antibody response to pneumococcal vaccine in splenectomized adults and adolescents. Acta Pathol Microbiol Immunol Scand C. 1982 Oct;90(5):257–263. doi: 10.1111/j.1699-0463.1982.tb01447.x. [DOI] [PubMed] [Google Scholar]
  17. Persson M. A., Hammarström L., Smith C. I. Enzyme-linked immunosorbent assay for subclass distribution of human IgG and IgA antigen-specific antibodies. J Immunol Methods. 1985 Apr 8;78(1):109–121. doi: 10.1016/0022-1759(85)90334-5. [DOI] [PubMed] [Google Scholar]
  18. Siber G. R., Weitzman S. A., Aisenberg A. C., Weinstein H. J., Schiffman G. Impaired antibody response to pneumococcal vaccine after treatment for Hodgkin's disease. N Engl J Med. 1978 Aug 31;299(9):442–448. doi: 10.1056/NEJM197808312990903. [DOI] [PubMed] [Google Scholar]
  19. Sullivan J. L., Ochs H. D., Schiffman G., Hammerschlag M. R., Miser J., Vichinsky E., Wedgwood R. J. Immune response after splenectomy. Lancet. 1978 Jan 28;1(8057):178–181. doi: 10.1016/s0140-6736(78)90612-8. [DOI] [PubMed] [Google Scholar]
  20. Szu S. C., Clarke S., Robbins J. B. Protection against pneumococcal infection in mice conferred by phosphocholine-binding antibodies: specificity of the phosphocholine binding and relation to several types. Infect Immun. 1983 Feb;39(2):993–999. doi: 10.1128/iai.39.2.993-999.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Weitzman S. A., Aisenberg A. C., Siber G. R., Smith D. H. Impaired humoral immunity in treated Hodgkin's disease. N Engl J Med. 1977 Aug 4;297(5):245–248. doi: 10.1056/NEJM197708042970504. [DOI] [PubMed] [Google Scholar]

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