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. 2006 Aug 17;116(9):2521–2531. doi: 10.1172/JCI28057

Figure 10. Prevention of colitis by ex vivo expanded PTEN-ΔT Tregs.

Figure 10

Rag1–/– mice were injected with 6 × 106 freshly isolated wild-type CD4+CD25–CD45RBhi cells either alone (n = 5) or together with 3 × 106 freshly isolated wild-type Tregs (n = 5) or PTEN-ΔT Tregs that had been expanded for 5 days ex vivo with rIL-2 (n = 7). (A) Body weight is represented as percentage of initial weight 8 weeks after transfer. Statistical analysis was performed using an unpaired 2-tailed Student’s t test. (B) Severity of colitis was histologically scored as described previously (25).