Figure 6. PTEN-ΔT Tregs exhibit enhanced homeostatic expansion in the periphery.
PTEN-ΔT mice and littermate controls were administered 1 mg BrdU every 12 hours for 3 days, at which time they were sacrificed and thymus and spleen cells were stained for BrdU. (A) Levels of BrdU incorporation in CD4+CD8–CD25+ and CD4+CD8–CD25– thymocytes. (B) Levels of BrdU incorporation in CD4+CD25+ and CD4+CD25– splenocytes. (C) Percentage BrdU-positive CD4+CD25+ and CD4+CD25– splenocytes from PTEN-ΔT mice (n = 6) and littermate controls (n = 6).