Figure 1.
Behavior of β-ERKO (○) and β-WT (■) mice in the social recognition test. Unlike their WT littermates, β-ERKO mice showed neither decreasing investigation of a repeatedly presented intruder mouse (tests 1–4) nor increased investigation of a new intruder at test 5. (A) β-ERKO mice were selectively impaired in social recognition but not in overall activity, because at test 5, they showed augmented nonsocial investigation (B) as well as a generalized increased activity (C). Consistently, their social anxiety-related behavior of stretched approaches toward the intruder was lower than the β-WT mice (D). **, P < 0.01 in comparison β-ERKO vs. β-WT.