Skip to main content
. 2001 Dec;134(7):1548–1554. doi: 10.1038/sj.bjp.0704415

Figure 4.

Figure 4

Effects of 1-EBIO and NS 1619 on whole-cell currents. (a) Typical whole-cell current recording from a freshly isolated endothelial cell under control conditions. (b,d) Current (I)-voltage (V) relationship for K-current in endothelial cells generated from a holding potential of −60 mV followed by a step to +50 mV and a subsequent 1.5 s voltage ramp to −150 mV, in the absence and presence of 1-EBIO (600 μM) and with the addition of ChTX (250 nM, b); or NS 1619 (33 μM, d). (c,e) I – V relationship for K-current in smooth muscle cells from a holding potential of −10 mV to test potentials of −150 to +50 mV (500 mS voltage steps) in the absence and presence of 1-EBIO (c); or from a holding potential of −10 mV to test potentials of −150 to +50 mV with either NS 1619 or NS 1619 and IbTX (250 nM, e). Each point represents the mean±s.e.mean (n=4).