Figure 1.
Photomicrographs of the CA1 area of the rat hippocampus. (A) Control section, showing the CA1 neurons as clear, rounded cells in a well-organized layer. (B) Following the administration of a combination of quinolinic acid 80 nmols with xanthine/xanthine oxidase (100 μM with 0.1 U ml−1), the CA1 layer is largely devoid of neurons, leaving a disorganized layer with a few neurons remaining intact (arrows). (C) The co-administration of ZM241385 together with quinolinic acid and the xanthine/xanthine oxidase mixture protects against the damage, leaving a largely intact cell layer in this example. Scale bar:-100 μM.