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Histogram illustrating the extent of neuronal damage induced by intrahippocampal injections of quinolinic acid 80 nmols in combination with SNAP 500 nmols. A highly significant degree of neuronal loss is produced by this combination, which is prevented by the simultaneous administration of chlorostyrylcaffeine (CSC), ZM241385 (ZM) or SCH58261 (SCH). The columns show the mean±s.e.mean (n=4) of the percentage of neurons surviving in the CA1 region of the counted sections. ***P<0.001.
