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. 2006 Sep;26(18):6859–6869. doi: 10.1128/MCB.00062-06

TABLE 2.

Selected p53-responsive genes not significantly affected by the K317R mutationa

Gene Alias Description mRNA level in IR-treated wt cells/mRNA level in untreated wt cells
mRNA level in IR-treated p53K317R cells/mRNA level in IR-treated wt cells
Ratio P value Ratio P value
Ccng1 Cyclin G Cyclin G 4.68 2.0 × 10−4 1.11 0.15
Bax Bcl2-associated X protein 3.70 5.2 × 10−5 1.13 0.24
Trp53inp1 Teap Trp53-inducible nuclear protein 1 2.78 1.2 × 10−5 1.09 0.36
Ppm1d Wip1 Protein phosphatase 1D, Mg dependent, delta 2.08 8.3 × 10−4 1.08 0.54
Cdkn1a p21 Cyclin-dependent kinase inhibitor 1A 1.91 2.8 × 10−2 1.11 0.30
Top2b Topoisomerase (DNA) II beta 1.46 2.3 × 10−3 0.98 0.84
Btg1 B-cell translocation gene 1, antiproliferative 1.46 3.4 × 10−3 1.08 0.36
Mtap4 Microtubule-associated protein 4 1.38 6.4 × 10−4 0.93 0.28
Tnfrsf10b Killer Tumor necrosis factor receptor superfamily member 1.30 3.8 × 10−2 1.00 0.99
Mdm2 Transformed mouse 3T3 cell double-minute 2 1.27 4.5 × 10−2 1.05 0.41
Pcna Proliferating cell nuclear antigen 0.98 6.1 × 10−1 0.86 0.30
Gadd45a Growth arrest and DNA damage-inducible 45 alpha 0.89 1.2 × 10−2 1.13 0.22
Xpc Xeroderma pigmentosum, complement, group C 0.85 3.6 × 10−2 0.99 0.90
Birc5 Survivin Baculoviral IAP repeat-containing 5 0.83 7.2 × 10−2 0.90 0.09
Plk1 Polo-like kinase homolog (Drosophila) 0.63 5.4 × 10−4 1.20 0.15
Cdc25c Cell division cycle 25 homolog C (S. cerevisiae) 0.61 1.5 × 10−3 0.98 0.86
Gsn Gelsolin 0.51 1.4 × 10−5 1.01 0.90
Cdc2a Cell division cycle 2 homolog A (Schizosaccharomyces pombe) 0.51 4.8 × 10−4 0.89 0.11
Ccnb2 Cyclin B2 Cyclin B2 0.49 5.0 × 10−4 1.09 0.21
Myc Myelocytomatosis oncogene 0.19 6.5 × 10−5 0.83 0.09
a

wt, wild-type.