Table 1. Effect of prostaglandins on MRP-mediated transport.
| PG | μM | MRP4 | MRP1 | MRP2 | MRP3 | MRP5 |
|---|---|---|---|---|---|---|
| PGE1 | 1 | 67 ± 7 | ||||
| 5 | 18 ± 4 | |||||
| 20 | 4 ± 2 | 87 ± 4 | 162 ± 7 | 94 ± 5 | 69 ± 4 | |
| PGE2 | 1 | 66 ± 1 | ||||
| 5 | 35 ± 5 | |||||
| 20 | 9 ± 2 | 98 ± 5 | 131 ± 1 | 86 ± 1 | 74 ± 3 | |
| PGF1α | 1 | 79 ± 4 | ||||
| 5 | 62 ± 1 | |||||
| 20 | 29 ± 1 | 91 ± 4 | 138 ± 5 | 107 ± 3 | 87 ± 3 | |
| PGF2α | 1 | 74 ± 1 | ||||
| 5 | 42 ± 1 | |||||
| 20 | 15 ± 2 | 107 ± 7 | 166 ± 10 | 101 ± 5 | 63 ± 3 | |
| PGA1 | 1 | 53 ± 1 | ||||
| 5 | 18 ± 5 | |||||
| 20 | 2 ± 2 | 83 ± 3 | 182 ± 9 | 76 ± 1 | 51 ± 1 | |
| TXB2 | 1 | 89 ± 1 | ||||
| 5 | 56 ± 3 | |||||
| 20 | 29 ± 6 | 66 ± 1 | 143 ± 10 | 76 ± 9 | 77 ± 10 |
Sf9 membrane vesicles containing MRP1, 2, 3, or 4 were incubated with 1 μM E2 17βG for 2 min; HEK293/MRP5 vesicles were incubated for 30 min with 1 μM alaninyl-d4TMP. Values are expressed as percentage of control and are the average ± SE of two independent experiments performed in triplicate.