Table 2.
Incidence of Diabetes According to Genotype at the rs12255372 and rs7903146 Variants.*
| Variable | No. of Participants | Genotype at rs12255372† | Hazard Ratio for GT vs. GG (95% CI) | P Value | GT P Value‡ | Hazard Ratio for TT vs. GG (95% CI) | P Value | TT P Value‡ | PAR | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GG | GT | TT | |||||||||
| no. of cases of diabetes (cases/100 person-yr) | |||||||||||
| Overall cohort | 2951 | 302 (7.4) | 260 (8.0) | 69 (10.6) | 1.08 (0.92–1.29) | 0.35 | — | 1.53 (1.17–2.01) | 0.002 | — | 0.11 |
| Whites | 1657 | 140 (6.8) | 165 (8.0) | 45 (10.8) | 1.19 (0.94–1.50) | 0.14 | — | 1.67 (1.18–2.37) | 0.004 | — | 0.14 |
| African Americans | 600 | 67 (8.6) | 56 (8.6) | 16 (10.3) | 1.02 (0.71–1.47) | 0.90 | 0.50 | 1.24 (0.70–2.17) | 0.46 | 0.35 | 0.13 |
| Hispanics | 489 | 62 (7.6) | 30 (6.7) | <15 (10.2) | 0.83 (0.53–1.31) | 0.42 | 0.18 | 1.70 (0.75–3.87) | 0.21 | 0.93 | 0.10 |
| Asians | 124 | 20 (8.0) | <15 (7.7) | <15 (13.0) | 0.88 (0.36–2.15) | 0.78 | 0.58 | 1.42 (0.17–11.7) | 0.75 | 0.95 | 0.18 |
| American Indians | 81 | <15 (6.6) | <15 (11.8) | <15 (0.0) | 1.93 (0.39–9.63) | 0.42 | 0.58 | NA | NA | 0.97 | NA |
| Genotype at rs7903146† | Hazard Ratio for CT vs. CC (95%3CI) | P Value | CT P Value‡ | Hazard Ratio for TT vs. CC (95% CI) | P Value | TT P Value‡ | PAR | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | |||||||||
| no. of cases of diabetes (cases/100 person-yr) | |||||||||||
| Overall cohort | 2983 | 305 (7.6) | 255 (7.6) | 77 (10.8) | 1.00 (0.84–1.19) | 0.99 | — | 1.55 (1.20–2.01) | <0.001 | — | 0.06 |
| Whites | 1671 | 147 (7.3) | 153 (7.4) | 51 (10.9) | 1.03 (0.81–1.30) | 0.82 | — | 1.62 (1.16–2.25) | 0.004 | — | 0.05 |
| African Americans | 605 | 64 (8.5) | 62 (8.9) | <15 (9.7) | 1.09 (0.76–1.56) | 0.65 | 0.82 | 1.20 (0.66–2.17) | 0.55 | 0.36 | 0.10 |
| Hispanics | 497 | 61 (7.4) | 29 (6.6) | <15 (12.7) | 0.89 (0.56–1.41) | 0.62 | 0.60 | 2.26 (1.14–4.50) | 0.02 | 0.46 | 0.18 |
| Asians | 128 | 22 (9.2) | <15 (6.4) | <15 (8.9) | 0.55 (0.23–1.33) | 0.19 | 0.26 | 0.92 (0.11–7.48) | 0.94 | 0.66 | −0.12 |
| American Indians | 82 | <15 (6.7) | <15 (7.5) | <15 (0.0) | 1.15 (0.35–3.78) | 0.82 | 0.84 | NA | NA | 0.97 | NA |
*
CI denotes 95 percent confidence interval, PAR population attributable risk (calculated with data from the placebo group), and NA not available because of insufficient data.
†
In instances where the number of cases is less than 15, exact numbers were not reported to protect the confidentiality of participants, per DPP publication policy.
‡
The P value is for the interaction between the genotype and the race or ethnic group, with the largest groups (whites and those who were homozygous for the major allele) serving as the reference group.