Table 2.
Biochemical measures in ZDF rats at 6 and 12 weeks that received daily treatment with NAC, AG, SMT, or saline
| ZDF 6w | ZDF 12w
|
||||
|---|---|---|---|---|---|
| Vehicle | NAC | AG | SMT | ||
| Number | 10 | 15 | 15 | 15 | 15 |
| Body weight (g) | 166.8 ± 6.9 | 347.8 ± 4.5* | 365.0 ± 6.0* | 364.9 ± 6.8* | 352.8 ± 6.4* |
| Nonfasted glucose (mg/ml) | 137.4 ± 3.7 | 489.3 ± 44.3* | 284.3 ± 18.7‡§ | 243.2 ± 24.8†§ | 423.7 ± 25.3* |
| 8OHdG (ng/ml) | 70.5 ± 11.2 | 118.4 ± 9.0† | 78.6 ± 4.9¶ | 72.8 ± 3.2¶ | |
| MDA + 4HNE (μM) | 1.26 ± 0.10 | 2.26 ± 0.35‡ | 1.61 ± 0.08‖ | 1.38 ± 0.17‖ | |
| OGTT | |||||
| AUC-glucose (g/ml⋅min) | 23.3 ± 2.3 | 47.1 ± 5.6* | 29.9 ± 2.7¶ | 25.3 ± 1.7§ | 42.1 ± 4.4* |
| Insulin response (microunits/ml) | 47.3 ± 9.3 | 55.9 ± 9.4 | 134.8 ± 29.9‖ | 147.0 ± 34.0‖ | 83.6 ± 20.1 |
| Urinary glucose | 2.74 ± 0.77 | 0.75 ± 0.11§ | 0.55 ± 0.14§ | 2.44 ± 0.32 | |
| excretion (g/24 h) | |||||
| Insulin content is islets | 20.3 ± 3.6 | 30.9 ± 6.0 | 92.5 ± 20.5‖ | 183.2 ± 34.7§ | 42.3 ± 6.7 |
| (microunits/ml per 50 islets) | |||||
*
, P < 0.001;
†
, P < 0.01;
‡
, P < 0.05 vs. 6-week data;
§
, P < 0.001;
¶
, P < 0.01,
‖
, P < 0.05 vs. vehicle treatment.
MDA, malondialdehyde.