Table 1.
Mammalian FMOs purified or expressed
| Species | FMO | Purified or expressed | Reference |
|---|---|---|---|
| FMO1 | |||
| Dog | 1 | Expressed—baculovirus | Stevens et al., 2003 |
| Human | 1 (wild-type) plus four allelic variants | Expressed—baculovirus | Furnes & Schlenk, 2004 |
| Human | 1 | Expressed—baculovirus | Yeung et al., 2000 |
| Mouse | 1, 3a | Purified—kidney | Venkatesh et al., 1991a, 1991b |
| Mouse | Liver | Purified | Smyser et al., 1985 |
| Mouse | 1 and 5a | Expressed—E. coli | Cherrington et al., 1998 |
| Pig | 1 | Purified | Ziegler & Mitchell, 1972 |
| Pig | 1 | Expressed—E. coli | Lomri et al., 1993 |
| Rabbit | 1, 2, 3, 5 | E. coli | Rettie et al., 1994 |
| Rabbit | 1 | Expressed—Cos-1 cells | Lawton et al., 1991 |
| Rabbit | 1, 3 | Purified—liver | Ozols, 1991, 1994 |
| Rat | 1 | Expressed—yeast | Chiba et al., 1995 |
| Rat | 1 and 3a | Purified—liver | Krause et al., 1996 |
| Rat | 1 | Expressed—yeast | Itoh et al., 1993 |
| Rat | Purified—liver | Kimura et al., 1983 | |
| Sheep | 1, 3a | Purified—liver | Longin-Sauvageon et al., 1998 |
| FMO2 | |||
| Human | 2 | Expressed—baculovirus | Dolphin et al., 1998 |
| Human | 2 (wild-type) plus five allelic variants | Expressed—baculovirus | Krueger et al., 2002a, in press |
| Monkey | 2 | Expressed—baculovirus | Krueger et al., 2001 |
| Mouse | Purified—lung and liver | Tynes et al., 1985 | |
| Mouse | 2 | Expressed—E. coli | Karoly & Rose, 2001 |
| Mouse | Lung | Purified | Venkatesh et al., 1992 |
| Rabbit | 2 | Purified—lung | Williams et al., 1984, 1985 |
| Rabbit | 2 | Purified—lung and liver | Tynes et al., 1985 |
| Rabbit | 2 | Expressed—COS-1 cells | Lawton et al., 1991 |
| Rabbit | 2 | Expressed—baculovirus | Krueger et al., 2001 |
| Rabbit | 3 (1C1) | Expressed—E. coli | Atta-Asafo-Adjei et al., 1993 |
| Rat | 2b | Expressed—E. coli | Lattard et al., 2002 |
| FMO3 | |||
| Human | 3 | Expressed—E. coli fusion | Brunelle et al., 1997 |
| Human | 3 | Expressed—baculovirus | Haining et al., 1997 |
| Human | 3 (wild-type) plus three allelic variants | Expressed—baculovirus | Furnes & Schlenk, 2004 |
| Monkey | 3 | Purified—liver | Sadeque et al., 1993 |
| Monkey | 3 | Purified—liver | Rettie et al., 1995 |
| Mouse | 3 | Expressed—E. coli | Falls et al., 1997 |
| Rat | 3 | Purified—liver | Moroni et al., 1995b |
| FMO4 and FMO5 | |||
| Human | 4 (modified) | Expressed—E. coli | Itagaki et al., 1996 |
| Human | ? | Purified—brain | Bhagwat et al., 1996a |
| Guinea Pig | 5 | Expressed—E. coli | Overby et al., 1995 |
| Human | 5 | Expressed—E. coli | Overby et al., 1995 |
a
FMO enzyme identity not definitively established.
b
Rat FMO2 is truncated and enzymatically inactive.